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FLASH GENE
Symbol FAU contributors: mct - updated : 09-03-2011
HGNC name Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30
HGNC id 3597
Location 11q13.1      Physical location : 64.888.098 - 64.889.672
Synonym name
  • 40S ribosomal protein S30
  • FAU-encoded ubiquitin-like protein
  • FBR-MuSV-associated ubiquitously expressed
  • Monoclonal nonspecific suppressor factor beta
  • Synonym symbol(s) FAU1, RPS30, FLJ22986, Fub1, Fubi, MNSFbeta, asr1
    DNA
    TYPE functioning gene
    STRUCTURE 1.57 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - MEN1 MEN1 - GPHA2 - SNX15 - ZFPL1 - TM7SF2 - FAU - D11S1963 - MRPL49 - SYVN1 -CAPN1 - POLA2 - TIGD3 - LTBP3 - KCNK7 - MAP3K11 -PCNXL3 - qter
    Authors GENATLAS from the Genome draft
    Physical map
    RASGRP2 11q13 RAS guanyl releasing protein 2 (calcium and DAG-regulated) PYGM 11q13.2 phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) SF1 11q13.2 splicing factor 1 MAP4K2 11q13 mitogen-activated protein kinase kinase kinase kinase 2 MEN1 11q13.2 multiple endocrine neoplasia I HSMDPKIN 11q13 multiple endocrine neoplasia I EHD1 11q13 EH-domain containing 1 KIAA0404 11q13.3-q13.5 EH-domain containing 1 PPP2R5B 11q13 protein phosphatase 2, regulatory subunit B (B56), beta isoform GPHA2 11q13.1 glycoprotein hormone alpha 2 LOC283129 11q13.1 hypothetical protein LOC283129 LOC116071 11q13.1 hypothetical protein BC012330 SNX15 11q12 sorting nexin 15 ARL2 11q13 ADP-ribosylation factor-like 2 LOC390210 11 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) HSU79266 11q13.1 protein predicted by clone 23627 NAALADL1 11q12 N-acetylated alpha-linked acidic dipeptidase-like 1 LOC256676 11q13.1 hypothetical LOC256676 CDCA5 11q12.1 cell division cycle associated 5 ZFPL1 11q13 zinc finger protein-like 1 C11orf2 11q13 chromosome 11 open reading frame2 TM7SF2 11q13 transmembrane 7 superfamily member 2 C11orf5 11q13 chromosome 11 open reading frame 5 FAU 11q12-q13.1 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30 MRPL49 11q13 mitochondrial ribosomal protein L49 HRD1 11q13 HRD1 protein LOC387778 11 similar to p33 ringo LOC387779 11 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CAPN1 11q13 calpain 1, (mu/I) large subunit LOC387780 11 similar to solute carrier family 22 member 6; organic cationic transporter-like 1; solute carrier family 22 (organic anion transporter), member 6 POLA2 11q13.1 polymerase (DNA-directed), alpha (70kD) CDC42EP2 11q13 CDC42 effector protein (Rho GTPase binding) 2 DPF2 11q13 D4, zinc and double PHD fingers family 2 TIGD3 11q13.2 tigger transposable element derived 3 LOC283130 11q13.1 hypothetical protein LOC283130 FKSG44 11q13 hypothetical protein FKSG44
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 579 - 133 - 2004 15543234
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    fusion protein consisting of the ubiquitin-like protein fubi (74 AA and 7.8 kDa) at the N terminus and ribosomal protein S30 ( 59 AA and 6.6 kDa) at the C terminus
    HOMOLOGY
    interspecies homolog to viral FOX/FBR-MuSV
    ortholog to murine Fau
    homolog to rattus Rn.5998
    homolog to zebrafish Dr.1455
    homolog to C.elegans C26F1.4
    Homologene
    FAMILY
  • ubiquitin-like family
  • S30E family of ribosomal proteins
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • fusion protein consisting of a ubiquitin-like segment (Ubi-L) and ribosomal protein S30
  • displays tumour suppressor and oncogenic properties in different contexts
  • might be implicated in the macrophage response to lipopolysaccharide
  • role for FAU in the regulation of platinum-resistance in ovarian cancer
  • covalently conjugates to SH3GL1, a member of the endophilin A family, and inhibits phagocytosis by macrophages
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the 40S subunit of the cytoplasmic ribosome (ribosomal protein S30)
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • post-translational modification of SH3GL1 by FAU might be implicated in phagocytosis by macrophages
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    dysregulated expression of FAU and MELK is associated with poor prognosis in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS