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FLASH GENE
Symbol FAT3 contributors: mct - updated : 30-10-2012
HGNC name FAT tumor suppressor homolog 3 (Drosophila)
HGNC id 23112
Location 11q14.3      Physical location : 92.085.261 - 92.629.633
Synonym name
  • FAT tumor suppressor homolog 3
  • protocadherin Fat 3
  • cadherin family member 15
  • cadherin-related family member 10
  • Synonym symbol(s) KIAA1989, CDHF15, CDHR10
    DNA
    TYPE functioning gene
    STRUCTURE 544.37 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387802 11 similar to RING finger protein 18 (Testis-specific ring-finger protein) LOC387803 11 hypothetical gene supported by NM_024114 LOC390238 11 similar to tripartite motif-containing 43 LOC120144 11q14.3 similar to autoantigen NOR-90 NAALAD2 11q14.3-q21 N-acetylated alpha-linked acidic dipeptidase 2 CHORDC1 11q14.2 cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1 LOC143712 11q14.3 similar to tubulin, alpha 2; tubulin alpha 2 LOC390239 11 similar to NADH-ubiquinone oxidoreductase ESSS subunit, mitochondrial precursor (Complex I-ESSS) (CI-ESSS) (Neuronal protein 17.3) (p17.3) (Np17.3) (UNQ111/PRO1064) LOC120105 11q14.3 similar to fat3; fat3 protein LOC390240 11 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) LOC390241 11 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) FAT3 11q14.3 FAT tumor suppressor homolog 3 (Drosophila) LOC341202 11q14.3 similar to Elongation factor 1-alpha 2 (EF-1-alpha-2) (Elongation factor 1 A-2) (eEF1A-2) (Statin S1) MTNR1B 11q21-q22 melatonin receptor 1B SLC36A4 11q14.3 solute carrier family 36 (proton/amino acid symporter), member 4 FLJ25393 11q21 hypothetical protein FLJ25393 FN5 11q13.3-q23.3 FN5 protein LOC390242 11 similar to N6-DNA-methyltransferase isoform 1; N6-DNA-methyltransferase MGC5306 11q21 hypothetical protein MGC5306 PTD012 11q21 PTD012 protein CRSP6 11q14 cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa LOC387804 11 LOC387804 LOC341208 11q21 hephaestin-like PANX1 11q21 pannexin 1 LOC387805 11 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) LOC390243 11 similar to folate receptor 3 GPR83 11q21 G protein-coupled receptor 83 MRE11A 11q21 MRE11 meiotic recombination 11 homolog A (S. cerevisiae) FGIF 11q21 fetal globin-inducing factor FUT4 11q21 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) HIWI2 11q21 piwi-like 2 (Drosophila) AMOTL1 11q14.3 angiomotin like 1 LOC390244 11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein HSPC148 11q21 hypothetical protein HSPC148
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 19048 502 4557 - 2012 23076869
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousspinal cord    
    cell lineage
    cell lines tumor cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text late embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cadherin domain
  • epidermal growth factor (EGF)-like motif
  • a laminin A-G motif and a cytoplasmic domain
  • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • FAT3 family
  • CATEGORY secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing an important role in axon fasciculation and modulation of the extracellular space surrounding axons during embryonic development
  • atypical cadherin FAT3 ensures that amacrine cells develop this unipolar morphology
  • FAT3 and FAT4 synergize potentially to drive vertebral arch fusion at the dorsal midline during caudal vertebra morphogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS