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FLASH GENE
Symbol FAT2 contributors: KTN/npt - updated : 03/12/2008
HGNC name FAT tumor suppressor homolog 2 (Drosophila)
HGNC id 3596
Location 5q33.1      Physical location : 150.883.653 - 150.948.505
Synonym name
  • multiple epidermal growth factor-like motif 1
  • protocadherin FAT2
  • cadherin family member 8
  • Synonym symbol(s) MEGF1, CDHF8, HFAT2, KIAA0811
    DNA
    TYPE functioning gene
    STRUCTURE 64.85 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 14565 479.2 4349 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     mouth   highly
    Endocrineneuroendocrinepituitary  moderately
     parathyroid   predominantly
    Nervousbrain    
    Reproductivefemale systemovary  moderately
    Respiratoryrespiratory tractlarynx  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 18 aa signal peptide
  • thirty two cadherin motifs
  • a laminin G-like domain
  • two EGF-like motifs
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog FAT2 (88.5 pc)
    homolog to chimpanzee FAT2 (99.3 pc)
    homolog to cow FAT2 (87 pc)
    homolog to rattus Fat2 (81.8 pc)
    homolog to murine Fat2 (82 pc)
    Homologene
    FAMILY
  • cadherin superfamily
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    text
  • single-pass type I membrane protein
  • localized at immature adherens junctions
  • basic FUNCTION
  • controlling cell proliferation
  • playing an important role in cerebellum development
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • cerebellum development
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS