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FLASH GENE

Symbol

FASLG

contributors: mct/np - updated : 14-12-2013

HGNC name	Fas ligand (TNF superfamily, member 6)
HGNC id	11936

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CSS2 Canale-Smith syndrome 2
Location	1q24.3      Physical location : 172.628.184 - 172.636.010
Synonym name	apoptosis (APO-1) antigen ligand 1
	tumor necrosis factor (ligand) superfamily, member 6
Synonym symbol(s)	FASL, APT1LG1, TNFSF6, CD178, CD95L

DNA

TYPE	functioning gene
STRUCTURE	7.83 kb     4 Exon(s)

regulatory sequence	Promoter
	Binding site
text structure	potential NR5A2 binding sites within the FASLG promoter

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000639 4 - 1909 NP_000630 31.4 281 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Reproductive female system ovary       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Lymphoid         Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic NK cell Nervous astrocyte Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracellular C terminus, which binds to the Fas receptor, triggering apoptosis via activation of a caspase cascade
	an intracellular domain (ICD) consistent with its ability to transduce signals, including a 26 AA proline-rich region that interacts with proteins containing Src homology 3 (SH3) and WW domains

conjugated

GlycoP

mono polymer

homomer , trimer

HOMOLOGY

interspecies	ortholog to rattus Tnfsf6
	ortholog to murine Fasl

Homologene

FAMILY

tumor necrosis factor (ligand) superfamily

CATEGORY

adaptor , antigen , signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	may be released into the extracellular fluid, probably by cleavage form the cell surface
	integral to plasma membrane
	predominantly retained inside the cell, presumably to limit cell surface expression and extracellular release of this pro-apoptotic ligand
	type II membrane protein

basic FUNCTION	FAS ligand, a pro-apoptotic protein induced by DNA damage
	major effector molecule of cytotoxic T lymphocytes
	critical skin homeostasis, not major contributing factor in the systemic lupus erythematosus
	plays a pivotal role in the regulation of apoptosis within and outside the immune system
	involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity
	essential for the growth of many tumour cells
	FAS/FASLG system plays a central role in maintaining peripheral immune tolerance
	rotative stress has a significant effect on CA2, FAS, FASLG, OSCAR, and TRAP gene expression in osteoclasts
	both ADAM10 and ADAM17 are associated with FASLG-containing secretory lysosomes
	is a cell death-promoting member of the tumor necrosis factor family with important functions in the regulation of T-cell homeostasis and cytotoxicity

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

positive regulation of I-kappaB kinase/NF-kappaB cascade

a component	trimerization may be dependent of FASLG or independent
	N-glycosylated
	FAS/FASLG induces erythroblast apoptosis

INTERACTION

DNA

RNA

small molecule

protein	interaction with ADAM10 may be of critical importance for the tight regulation of induced cell death in health and disease
	interacting with GRB2 (promotes sorting of FASLG to the cell surface, and, dynamic regulation of its cell surface localization is critical for controlling local tissue remodeling and inflammation)
	CCL2 modulate macrophage cytotoxicity by increasing the level of membrane bound FASLG
	NR5A2 regulates FASLG transcription and associated T-cell effector functions

cell & other

REGULATION

activated by

THY1 (THY1 up-regulates FASLG expression in lung myofibroblasts via Src family kinases)

Other

regulated by ADAM10 (ADAM10 is critically involved in the shedding of FASLG)

ASSOCIATED DISORDERS

corresponding disease(s)

CSS2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS