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FLASH GENE
Symbol FARSB contributors: np - updated : 24-02-2006
HGNC name phenylalanyl-tRNA synthetase, beta subunit
HGNC id 17800
Location 2q36.1      Physical location : 223.436.161 - 223.520.827
Synonym name
  • phenylalanine-- tRNA ligase beta chain
  • phenylalanine-tRNA synthetase-like, beta subunit
  • phenylalanine tRNA ligase 1, beta, cytoplasmic
  • Synonym symbol(s) FRSB, PheHB, FARSLB, HSPC173, PheRS
    EC.number 6.1.1.20
    DNA
    TYPE functioning gene
    STRUCTURE 85.00 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2233 66 589 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemtestis   
    Skin/Tegumentskin    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure two alpha and two beta chains
    mono polymer dimer
    HOMOLOGY
    interspecies ortholog to murine Farslb
    Homologene
    FAMILY
  • phenylalanyl-tRNA synthetase beta chain family
  • type 2 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • phenylalanine-tRNA ligase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerizing with FARSA in chronic myeloid leukemia cells
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       protein chimeric
    (alpha-beta)2 heterodimer in chronic myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS