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FLASH GENE
Symbol FARSA contributors: np - updated : 12-12-2007
HGNC name phenylalanyl-tRNA synthetase, alpha subunit
HGNC id 3592
Location 19p13.2      Physical location : 13.033.283 - 13.044.558
Synonym name
  • tRNA synthetase-like protein
  • phenylalanine-tRNA synthetase-like
  • phenylalanine-tRNA synthetase-like, alpha subunit
  • phenylalanine tRNA ligase 1, alpha, cytoplasmic
  • Synonym symbol(s) CML33, FARSL, FRSA, PheHA, FARSLA, FARS, PheRS
    EC.number 6.1.1.20
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     13 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1853 57 508 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     mouthtongue   
    Lymphoid/Immunespleen    
    Reproductivemale systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae phenylalanine-tRNA synthetase
    Homologene
    FAMILY
  • aminoacyl-tRNA synthetase (class-II) family
  • Phe-tRNA synthetase alpha chain subfamily 2
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in pathogenesis, phenylalanyl-tRNA aminoacylation
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with FARSB in chronic myeloid leukemia cells
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with FARSB in chronic myeloid leukemia cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS