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FLASH GENE
Symbol FARP2 contributors: npt/mct - updated : 23-09-2009
HGNC name FERM, RhoGEF and pleckstrin domain protein 2
HGNC id 16460
Location 2q37.3      Physical location : 242.295.663 - 242.434.255
Synonym name
  • FGD1-related Cdc42-GEF
  • FERM domain including RhoGEF
  • Synonym symbol(s) FIR, KIAA0793, PLEKHC3, FRG
    DNA
    TYPE functioning gene
    STRUCTURE 138.54 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 3997 119.7 1054 - Miyamoto (2003)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   moderately
    Lymphoid/Immunespleen   moderately
    Nervousbrain   highly
    Urinarykidney   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two PH domains
  • HOMOLOGY
    interspecies homolog to Drosophila CG1283
    homolog to C.elegans frm-3
    Homologene
    FAMILY
    CATEGORY unknown/unspecified , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • plays an important role in the signaling pathway downstream of G protein-coupled receptors (Miyamoto 2003)
  • guanine-nucleotide exchange factors for CDC42 (Miyamoto 2003)
  • key molecule involved in the response of neuronal growth cones to class-3 semaphorins (Toyofuku 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in autism with deletion 2q37.3 (Feider 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS