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FLASH GENE
Symbol FARP1 contributors: mct - updated : 30-08-2014
HGNC name FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
HGNC id 3591
Location 13q32.2      Physical location : 98.795.433 - 99.102.016
Synonym name
  • chondrocyte derived ezrin-like protein
  • PH domain-containing family C member 2
  • protein phosphatase 1, regulatory subunit 75
  • pleckstrin homology domain-containing family C member 2
  • Synonym symbol(s) CDEP, PLEKHC2, MGC87400, CDEP-IT1, PPP1R75
    DNA
    TYPE functioning gene
    STRUCTURE 307.21 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CLDN10 13q31-q34 claudin 10 DZIP1 13q32.1 claudin 10 DNAJC3 13q32 DnaJ (Hsp40) homolog, subfamily C, member 3 UGCGL2 13q32.1 UDP-glucose ceramide glucosyltransferase-like 2 HS6ST3 13 heparan sulfate 6-O-sulfotransferase 3 LOC283476 13q32.2 hypothetical protein LOC283476 LOC390420 13 similar to heat shock protein 84 - mouse LOC341592 13q32.2 similar to tubby like protein 3 GPR80 13q32.2 G protein-coupled receptor 80 MBNL2 13q31.1 muscleblind-like 2 (Drosophila) RAP2A 13q34 RAP2A, member of RAS oncogene family LOC121906 13q32.2 similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (27 kDa prosomal protein) (PROS-27) (p27K) LOC387943 13 LOC387943 KPNB3 13q32.2 karyopherin (importin) beta 3 FARP1 13q32.2-q32.3 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) ZNF183L1 13q zinc finger protein 183-like 1 STK24 13q32 serine/threonine kinase 24 (STE20 homolog, yeast) HCP35 13q32.3 cytochrome c, somatic pseudogene SLC15A1 13q33-q34 solute carrier family 15 (oligopeptide transporter), member 1 DOCK9 13q32.1 dedicator of cytokinesis 9 LOC390421 13 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) PHGDHL1 13 phosphoglycerate dehydrogenase like 1 GPR18 13q32 G protein-coupled receptor 18 EBI2 13q32.3 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) LOC390422 13 similar to Epstein-Barr virus induced gene 2 TM9SF2 13q32.2 transmembrane 9 superfamily member 2 CLYBL 13q32.3 citrate lyase beta like ZIC5 13q32.2 Zic family member 5 (odd-paired homolog, Drosophila) ZIC2 13q32 Zic family member 2 (odd-paired homolog, Drosophila) PCCA 13q32 propionyl Coenzyme A carboxylase, alpha polypeptide LOC87769 13q32.3 hypothetical protein BC004360 FLJ14624 13q32.3 hypothetical protein FLJ14624
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 5022 118 1045 - 1997 9425278
    3 - 1419 - 129 - 1997 9425278
    28 - 4936 - 1076 - 1997 9425278
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
     chondrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ezrin-like domain, Dbl homology (DH)
  • two pleckstrin homology (PH) domains
  • HOMOLOGY
    Homologene
    FAMILY Rho GEF family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • Rho guanyl-nucleotide exchange factor activity
  • regulates dendritic filopodial dynamics in immature neurons, indicating roles in synapse formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • serves as a specific effector of transmembrane SEMA6A and PLXNA4 signals to regulate lateral motor column (LMC) dendritic growth
  • triggers a retrograde signal regulating active zone composition via CADM1
  • interacts with the Neuropilin-1/PLXNA1 complex and colocalizes with PLXNA1 along dendritic shafts
  • FARP1 is required by SEMA3A to promote dendritic arborization of hippocampal neurons, and Sema3A regulates dendritic F-actin distribution via FARP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS