protein
| with ATM (phosphorylation of FANCD2 for regulating discrete cellular signaling pathway) |
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with BRCA2 and FANCG in DNA damage response pathway |
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complexing with BRCA1 and RAD51 |
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interacting with menin (MEN1)for critical role in repair of DNA damage |
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interaction with BRCA2 (monoubiquitination of FANCD2, which is regulated by the FA pathway, promotes BRCA2 loading into chromatin complexes) |
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associating with USP1 |
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FANCE-mediated association of FANCC with FANCD2 |
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interacting with FANCM (FANCM and FANCD2 are functionally interdependent) |
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FANCI-FANCD2 complex preferentially binds to the branched DNA structures when compared with either FANCI or FANCD2 alone |
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interacting with UBE2T (with Fanconi anemia (FA) nuclear core complex, are required for the S phase and DNA damage-restricted monoubiquitination of FANCD2) |
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upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 and relocalizes to chromatin, where it functions with monoubiquitinated FANCD2 to facilitate DNA repair |
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interaction with FAN1 (recruitment of FAN1 to mitomycin C-induced foci is dependent on FANCD2 ubiquitylation, and this interaction represent strong evidence in support of an involvement of this nuclease in the FA-dependent pathway of ICL repair) |
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recruited in response to replication stress and BRIP1 may serve to link FANCD2 to BRCA1 |
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interacts with CEBPD (CEBPD mediates the indirect association of FANCD2 with IPO4 through its interaction with both of these proteins via separate domains) |
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RAD18 binds FANCD2 and is required for efficient monoubiquitylation and chromatin localization of both FANCD2 and FANCI |
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BTBD12 is recruited to sites of DNA damage by monoubiquitylated FANCD2, and this recruitment requires its UBZ domain |
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DCLRE1B and FANCD2 function epistatically in cellular responses to mitomycin C -induced DNA damage to ensure survival |
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target for caspase-mediated apoptotic pathway, which may be an early indicator for apoptotic cell death |
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binding of FANCL with its partners, UBE2T, FANCD2, and FANCI |
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FANCD2 and FANCI have been identified as targets of FANCL monoubiquitylation |
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C1orf86 binds to FANCA subunit and is required for stability of the complex and monoubiquitination of FANCD2 |
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FANCD2-FANCI may regulate chromatin dynamics during DNA repair |
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DNA2 interacts with FANCD2, and cisplatin induces FANCD2 ubiquitylation even in the absence of DNA2 |
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in the early phase of DNA damage response, FANCD2 plays crucial roles in recruiting POLH to the sites of DNA damage for repair |
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activates transcription of TP63 and suppresses tumorigenesis |
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DCLRE1B is a nuclease required for efficient localization of the DNA repair proteins, FANCD2 and BRCA1 |
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can interact directly with minichromosome maintenance (MCM) proteins |
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ATR signaling promoted the transient association of endogenous FANCD2 with the MCM2-MCM7 replicative helicase independently of FANCD2 monoubiquitination |
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HELQ-deficient cells exhibited constitutive FANCD2 monoubiquitination, indicating that HELQ is dispensable for this modification |
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important regulatory role of the USP1-WDR48 complex in HR (homologous recombination) repair through its regulation of the FANCD2-ubiquitinated (Ub) and PCNA-Ub cellular pools |
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FAN1 joins the BLM-FANCD2 complex following APH-mediated fork stalling in a manner dependent on MRE11A and FANCD2, followed by FAN1 nuclease-mediated fork restart |
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is a novel and specific substrate of CASP3 (cleavage of FANCD2 by CASP3 did not require either the FA core complex or mono-ubiquitylation of FANCD2, and was stimulated by TP53) |
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FANCD2, BRIP1 and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex |
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USP1-WDR48 complex promotes homologous recombination (HR) repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1 |
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RUNX1 and RUNX3 also maintain genomic integrity in a non-transcriptional manner during interstand crosslink repair by promoting the recruitment of FANCD2 to sites of DNA damage |
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N-terminus of USP1 harbours a FANCD2-specific binding sequence required for deubiquitination of K561 on FANCD2 |
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DNAH2 may modulate the cell homologous recombination repair partially by increasing the ubiquitination and the enrichment to DNA damage sites of FANCD2 |