Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FAM3C contributors: SGE/npt - updated : 10-09-2009
HGNC name family with sequence similarity 3, member C
HGNC id 18664
Location 7q31.31      Physical location : 120.988.906 - 121.036.422
Synonym name
  • predicted osteoblast protein
  • protein FAM3C
  • interleukin-like EMT inducer
  • predicted osteoblast protein
  • interleukin-related protein interleukin-like EMT inducer
  • Synonym symbol(s) GS3876, GS3786, ILEI
    DNA
    TYPE functioning gene
    STRUCTURE 47.52 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D7S643 - D7S480 - FAM3C - D7S650 - D7S685 - qter
    Physical map
    LSM8 7q31.1-q31.3 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) ANKRD7 7q31 ankyrin repeat domain 7 KCND2 7q31-q32 potassium voltage-gated channel, Shal-related subfamily, member 2 TM4SF12 7 transmembrane 4 superfamily member 12 ING3 7q31 inhibitor of growth family, member 3 FLJ21986 7q31.32 hypothetical protein FLJ21986 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C HCP19 7q31.32 cytochrome c, somatic pseudogene LOC136143 7q31.32 similar to ribosomal protein L18; 60S ribosomal protein L18 PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 AASS 7q31.3 aminoadipate-semialdehyde synthase LOC389549 7 similar to zinc finger protein 312; forebrain embryonic zinc finger CADPS2 7q31.1 Ca2+-dependent activator protein for secretion 2 RNF133 7q31.33 ring finger protein 133 RNF148 7q31.33 ring finger protein 148 TAS2R16 7q31.1-q31.3 taste receptor, type 2, member 16 SLC13A1 7q31-q32 solute carrier family 13 (sodium/sulfate symporters), member 1 FLJ35834 7q31.33 hypothetical protein FLJ35834 NDUFA5 7q31.33 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa ASB15 7q31.31 ankyrin repeat and SOCS box-containing 15 LOC389550 7 similar to cardiac leiomodin WASL 7q31.3 Wiskott-Aldrich syndrome-like HYAL4 7q31.3 hyaluronoglucosaminidase 4 SPAM1 7q31.3 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) LOC340344 7q31.33 similar to RIKEN cDNA 6332401O19 gene LOC136157 7q31.33 similar to RIKEN cDNA 1500011L16 LOC346643 7q31.33 similar to 40S ribosomal protein S2 GPR37 7q31 G protein-coupled receptor 37 (endothelin receptor type B-like) LOC154872 7q31.33 hypothetical LOC154872
    RNA
    TRANSCRIPTS type messenger
    text Alternate transcriptional splice variants that encode the same protein were characterized
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2552 24.7 227 - -
    10 - 2512 24 227 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  lowly
     liver   highly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   lowly
    Nervousbrain   highly
    Reproductivefemale systemplacenta  highly
     female systemovary  lowly
     male systemtestis  lowly
     male systemprostate  lowly
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GG domain
  • a hydrophobic leader sequence
  • an N-terminal signal peptide
  • 4-helix bundle
  • HOMOLOGY
    interspecies ortholog to fam3c, Danio rerio
    ortholog to Fam3c, Mus musculus
    ortholog to Fam3c, Rattus norvegicus
    homolog to LOC463680, Pan troglodytes
    intraspecies homolog to FAM3A
    Homologene
    FAMILY
  • FAM3 family
  • CATEGORY secretory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • FAM3C is a tumor- and metastasis-inducing protein cooperates with oncogenic Ras to cause and maintain TGF-b-independent epithelial to mesenchymal transition (EMT) of hepatocyte (Lahsnig et al 2009)
  • collaboration of FAM3C with oncogenic Ras enhances tumor formation, nuclear accumulation of b-catenin and Stat3 tyrosine phosphorylation (Lahsnig et al 2009)
  • play a role in the EMT regulation
  • may be involved in retinal laminar formation processes (Katahira 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperates with oncogenic Ras
  • ILEI stimulates upregulation of PDGF-C/PDGF-Rb and enhances proliferation and migration in oncogenic Ras-expressing MIM-R-GFP hepatocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS