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FLASH GENE
Symbol FAM193A contributors: mct - updated : 24-05-2023
HGNC name family with sequence similarity 193, member A
HGNC id 16822
Location 4p16.3      Physical location : 2.627.158 - 2.734.301
Synonym name
  • res4-22 protein
  • chromosome 4 open reading frame 8
  • protein IT14
  • hypothetical protein LOC8603
  • Synonym symbol(s) RES4-22, C4orf8
    DNA
    TYPE functioning gene
    STRUCTURE 197.20 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located located close to the Huntington's disease gene (PMID: 9734812)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4742 135.83 1224 - 2023 36897777
    21 - 5155 - 1458 - 2023 36897777
    21 - 5522 - 1515 - 2023 36897777
    20 - 4797 - 1246 - 2023 36897777
    20 - 4854 - 1265 - 2023 36897777
    20 - 4824 - 1211 - 2023 36897777
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • FAM193 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FAM193A interacts with MDM4, and FAM193A depletion stabilizes MDM4 and inhibits the TP53 transcriptional program
  • FAM193A is a positive regulator of TP53
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS