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FLASH GENE
Symbol FAM188A contributors: mct - updated : 19-12-2012
HGNC name family with sequence similarity 188, member A
HGNC id 23578
Location 10p13      Physical location : 15.820.174 - 15.902.519
Synonym name
  • CARD-containing protein
  • caspase recruitment domain containing pro-apoptotic protein
  • dermal papilla derived protein 5
  • chromosome 10 open reading frame 97
  • Synonym symbol(s) CARP, DERP5, my042, FLJ13397, MST126, MSTP126, RP11-394I23.1, C10orf97
    DNA
    TYPE functioning gene
    STRUCTURE 82.34 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2375 49.7 445 - 2002 12054670
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver    
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative function domains
  • one CARD domain (aa 160-243)
  • one nuclear receptor-binding motif
  • two EF-hand motifs
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • having calcium ion binding activity
  • implicated in cardiac apoptosis
  • CARD-containing protein involved in recruitment of caspases and apoptosis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physical association between FAM188A and COPS5 (FAM188A functioning as a novel tumor suppressor by modulating several key G(1)/S-regulatory proteins by interacting with COPS5)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in non-small-cell lung cancer (NSCLC) tissue compared with normal lung tissue
    Susceptibility to hypertrophic cardiomyopathy
    Variant & Polymorphism other modifier gene of MYBPC3, in hypertrophic cardiomyopathy
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS