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FLASH GENE
Symbol FAM168A contributors: mct - updated : 19-05-2009
HGNC name family with sequence similarity 168, member A
HGNC id 28999
Location 11q13.4      Physical location : 73.117.027 - 73.309.228
Synonym name
  • KIAA0280
  • tongue cancer chemotherapy resistance-associated protein 1
  • hypothetical protein LOC23201
  • Synonym symbol(s) KIAA0280, TCRP1
    DNA
    TYPE functioning gene
    STRUCTURE 192.20 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1834 250 235 - Gerhard (2004)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestivemouthtongue  highly
    Lymphoid/Immunelymph node   moderately
    Nervousbrain   predominantly
    Reproductivefemale systemuteruscervix moderately
     female systemovary  highly
    Respiratoryrespiratory tractlarynx  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • FAM168 protein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • mediates a specific resistance to cisplatin in Tca8113 cells by reducing the cisplatin-induced apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    might be a novel molecular target to develop agents to reverse cisplatin-induced chemoresistance in cancer
    ANIMAL & CELL MODELS