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FLASH GENE
Symbol FAM13A contributors: mct/npt - updated : 25-06-2010
HGNC name family with sequence similarity 13, member A
HGNC id 19367
Location 4q22.1      Physical location : 89.647.105 - 89.978.323
Synonym name
  • family with sequence similarity 13, member A1
  • FAM13A1_v2 protein
    • Synonym symbol(s) KIAA0914, FAM13A1, FLJ34562, MGC105131
    DNA
    TYPE functioning gene
    STRUCTURE 331.22 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 5858 - 1023 - Cohen (2004)
    18 - 4919 - 697 - Cohen (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemovary   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a bipartite nuclear-localization signal
  • two coil-coiled domains
  • a Rho GTPase–activating protein (RhoGAP) domain
    • HOMOLOGY
    interspecies homolog to murine D430015B01
    intraspecies paralog to FAM13C1, C5orf5
    Homologene
    FAMILY
  • Fam13 family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • has a putative role in signal transduction (Cho 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to chronic obstructive pulmonary disease
    Variant & Polymorphism SNP rs7671167 strongly associated to chronic obstructive pulmonary disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS