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FLASH GENE
Symbol FAM129A contributors: mct - updated : 02-05-2012
HGNC name family with sequence similarity 129, member A
HGNC id 16784
Location 1q25.3      Physical location : 184.760.166 - 184.943.682
Synonym name
  • niban protein
  • chromosome 1 open reading frame 24
  • cell growth inhibiting protein 39
  • Synonym symbol(s) E11, NIBAN, C1orf24, GIG39
    DNA
    TYPE functioning gene
    STRUCTURE 183.52 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4002 - 726 - 2001 11318611
    14 - 6926 103.1 928 - 2001 11318611
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuterus   
     male systemtestis   
     male systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    DNAJ1 motif
    HOMOLOGY
    interspecies homolog to rattus niban
    homolog to murine Niban
    Homologene
    FAMILY niban family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • plays an important role in carcinogenesis
  • positively affects protein translation machineries
  • potentially involved in the ER stress response, and can modulate cell death signaling by regulating translation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in renal carcinoma
    tumoral     --other  
    its expression frequently begins in the early stages of head and neck squamous carcinoma and remains upregulated throughout the carcinogenic process
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • putative marker for characterization of follicular thyroid neoplasms
  • may be a good molecular marker of head and neck squamous cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS