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FLASH GENE
Symbol FAM120B contributors: npt/mct - updated : 15-01-2021
HGNC name family with sequence similarity 120B
HGNC id 21109
Location 6q27      Physical location : 170.615.843 - 170.714.236
Synonym name
  • KIAA1838
  • PPARgamma constitutive coactivator-1
  • constitutive coactivator of peroxisome proliferator-activated receptor gamma
  • senataxin-associated nuclease 1
    • Synonym symbol(s) KIAA1838, PGCC1, dJ894D12.1, FLJ55614, KIAA0183, CCPG, SAN1
    DNA
    TYPE functioning gene
    STRUCTURE 117.05 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3261 - 910 - 2018 29968717
    11 - 5440 - 922 - 2018 29968717
    11 - 5203 - 933 - 2018 29968717
    8 - 3219 - 242 - 2018 29968717
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinesmall intestine   
    Endocrineneuroendocrinepituitary   
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four LXXLL motifs, which are characteristic for nuclear receptor coactivators (Li 2007)
    • HOMOLOGY
    interspecies ortholog to murine 4932442K08Rik
    Homologene
    FAMILY
  • constitutive coactivator of PPAR-gamma family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized in nucleus (Li 2007)
    basic FUNCTION
  • coactivator that promotes adipogenesis in a PPARgamma-dependent manner (Li 2007)
  • is a 5' exonuclease that acts independently of the Fanconi anemia (FA) pathway in response to interstrand DNA cross-links (ICLs)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the hinge region of PPARgamma in a ligand-independent manner (Li 2007)
  • FAM120B binds to Senataxin (SETX), an RNA/DNA helicase that resolves R-loops
  • functions with SETX in a pathway necessary for resistance to interstrand DNA cross-links (ICLs)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS