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FLASH GENE
Symbol FAM120A contributors: mct/npt - updated : 28-04-2009
HGNC name family with sequence similarity 120A
HGNC id 13247
Location 9q22.31      Physical location : 96.214.172 - 96.328.396
Synonym name
  • constitutive coactivator of PPAR-gamma-like protein 1
  • chromosome 9 open reading frame 10
  • hypothetical protein LOC23196
  • oxidative stress-associated Src activator
  • DNA polymerase-transactivated protein 1
  • DNA polymerase-transactivated protein 5
  • Synonym symbol(s) MGC133257, MGC111527, KIAA0183, C9orf10, DNAPTP1, DNAPTP5, OSSA
    DNA
    TYPE functioning gene
    STRUCTURE 114.22 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4957 - 1118 - Holden (2003)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five putative tansmembrane domains
  • C-terminus having a distinct function that directly binds RNAs such as insulin-like growth factor II (IGF2) mRNA and promotes the extracellular secretion of IGF2 (Tanaka 2009)
  • HOMOLOGY
    interspecies ortholog to rattus RGD1306643_predicted
    Homologene
    FAMILY
  • FAM120 family
  • constitutive coactivator of PPAR-gamma family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • RNA-binding protein that guards cancer cells from oxidative stress-induced apoptosis by activation of SFK (Src family kinases) (Tanaka 2009)
  • protects cells from apoptosis through activation of SFKs in response to oxidative stress (Tanaka 2009)
  • may play a pivotal role in the progression of scirrhous-type gastric cancer (Tanaka 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA directly binds to RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in gastric scirrhous carcinoma (Tanaka 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cell (Tanaka 2009)
    ANIMAL & CELL MODELS