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FLASH GENE
Symbol FAM118B contributors: mct - updated : 20-12-2020
HGNC name family with sequence similarity 118, member B
HGNC id 26110
Location 11q24.2      Physical location : 126.081.618 - 126.132.879
Synonym name
  • FLJ21103 protein
  • hypothetical protein LOC79607
  • Synonym symbol(s) FLJ21103
    DNA
    TYPE functioning gene
    STRUCTURE 53.13 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1792 - 351 - 2014 24569877
    9 - 2090 - 350 - 2014 24569877
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus of FAM118B might contain a putative nucleolar localization signal (NoLS)and this region might allow FAM118B to shuttle between the nucleolus and Cajal bodies
  • a conserved SIR2-like domain between residues 159 and 301
  • HOMOLOGY
    interspecies ortholog to murine C030004A17Rik
    Homologene
    FAMILY
  • FAM118 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • localizes mainly in the nucleoplasm and concentrates at a few foci inside the nucleus, where it colocalizes with coilin
  • basic FUNCTION
  • FAM118B concentrated in Cajal bodies in control cells, but was diffusely localized in the nucleoplasm in coilin-depleted cells, suggesting that the foci formation of FAM118B is coilin dependent
  • is likely required for the assembly of Cajal bodies
  • FAM118B plays an important role in splicing and cell proliferation
  • is an important player not only in the formation of Cajal bodies, but also in the interaction of SMN with Sm proteins which is required for snRNP biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of Cajal bodies
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with coilin and SMN proteins
  • FAM118B, by regulating SNRPD1 symmetric dimethylarginine modification, plays an important role in Cajal body formation, snRNP biogenesis and cell viability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduces splicing capacity and inhibits cell proliferation
    tumoral fusion      
    YAP1-FAM118B in meningioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Yap1-Fam118B gene fusion is a potent oncogene capable of inducing brain tumors in mice