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FLASH GENE
Symbol FAM109A contributors: mct - updated : 18-10-2011
HGNC name family with sequence similarity 109, member A
HGNC id 26509
Location 12q24.11      Physical location : 111.798.455 - 111.806.925
Synonym name
  • inositol polyphosphate phosphatase interacting protein of 27 kDa (IPIP27)A
  • sesquipedalian 1
    • Synonym symbol(s) FLJ32356, IPIP27A, SES1
    DNA
    TYPE functioning gene
    STRUCTURE 8.47 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3149 - 249 - 2010 20133602
    3 - 3168 - 249 - 2010 20133602
    4 - 3256 - 262 - 2010 20133602
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text localize to early and recycling endosomes and the trans-Golgi network (TGN)
    basic FUNCTION
  • key player in endocytic trafficking
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component form homo- and heterodimers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the ASH-RhoGAP-like (ASPM-SPD-2-Hydin homology and Rho-GTPase Activating Domain-like) domain of OCRL
  • OCRL-binding protein, that also bind the related 5-phosphatase INPP5B
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS