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FLASH GENE
Symbol FAM107A contributors: mct/npt/pgu - updated : 07-07-2010
HGNC name family with sequence similarity 107, member A
HGNC id 30827
Location 3p14.3      Physical location : 58.549.846 - 58.563.491
Synonym name
  • homo sapiens TU3A protein (TU3A), mRNA
  • down-regulated in renal cell carcinoma 1
  • protein TU3A
  • Synonym symbol(s) DRR1, TU3A, FLJ45473, FLJ30158
    DNA
    TYPE functioning gene
    STRUCTURE 13.65 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - PDHB PDHB - [D3S1592 - D3S3406 - FAM107A - ACOX2 - D3S2452 - D3S1067 - D3S3368 - D3S1766 - D3S1313 ] - FHIT - cen
    Authors PMID: 10702698
    Text [commonly deleted in renal cell carcinoma]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3367 - 144 - 1999 10702698
    5 - 3465 - 144 - 1999 10702698
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
     brain   highly Homo sapiensDRR1 RNA
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed in normal cells, particularly in the nervous system during embryogenesis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear localization signal (NLS)
  • a coiled-coil domain
  • HOMOLOGY
    interspecies ortholog to murine Fam107A
    Homologene
    FAMILY
  • FAM107 family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • endogenous DRR1 localizes to some, but not all, synapses, with preference for the presynaptic region
  • basic FUNCTION
  • involved in the regulation of gene transcription and in the development of several cancers
  • involved in neuronal cell survival, and is downregulated during neuroblastoma carcinogenesis
  • stress- and glucocorticoid-responsive protein that impacts on F-actin formation, providing a direct molecular link between stress and actin-dependent processes
  • stress-induced protein in brain that binds to actin, promotes bundling and stabilization of actin filaments, and impacts on actin-dependent neurite outgrowth
  • does not degrade neurites, but profoundly affects actin-dependent structural reorganization in cells
  • may be involved in mediating the observed time- and context-dependent positive effects of stress on cognition
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in renal cell carcinoma
    tumoral     --low  
    by promoter hyper-methylation in several types of cancer cell lines and primary cancers of the bladder and testis
    tumoral     --low  
    during neuroblastoma carcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS