Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FAM101A contributors: mct - updated : 11-04-2012
HGNC name family with sequence similarity 101, member A
HGNC id 27051
Location 12q24.31      Physical location : 124.773.709 - 124.800.568
Genatlas name Refilin A
Synonym name
  • CDNA FLJ90064 fis, clone HEMBA1003487
  • REgulator of FILamin proteIN A
    • Synonym symbol(s) FLJ44614
    DNA
    TYPE functioning gene
    STRUCTURE 26.86 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2160 - 135 - 2011 21709252
    EXPRESSION
    Rna function mRNA is up-regulated during the commitment of multipotent neural precursor cells into glial progenitor cells
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • enriched in proline with a secondary structure predicted to be composed of beta structures and coiled domains lacking alpha helices
  • N-terminal sequence harboring a DSG(X)2–4S motif mediating degradation of short-lived proteins and also found in nuclear transcription factors involved in TGFB–dependent EMT signaling
  • at least two FLNA binding domains (BD2 and BD4)
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • specifically promote actin filament bundles to organize apical perinuclear actin networks in mesenchymal cells
  • function through binding to the actin binding protein FLNA and conversion of FLNA from an F-actin branching protein into an F-actin bundler
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RefilinA/RefilinB/FLNA complex organizes the perinuclear actin filament bundles forming the actin cap
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to the actin-binding filamins, FLNA, FLNB, and FLNC
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS