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FLASH GENE
Symbol FADS2 contributors: - updated : 12-07-2006
HGNC name fatty acid desaturase 2
HGNC id 3575
Location 11q12-q13.1      Physical location : 61.595.712 - 61.634.825
Synonym name linoleoyl CoA desaturase (delta 6 desaturase)-like 2
Synonym symbol(s) TU13, LLCDL2, D6D, DES6, FADSD6, SLL0262
EC.number 1.14.99.25
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text component of a cluster of fatty acid desaturase
STRUCTURE 39.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   hormone
motif repetitive sequence   ALU   long interspersed repetitive elements
text structure
  • two candidates of sterol regulatory element (SRE)
  • 5'-flanking region contains a direct repeat ( DR-1) that functions in the regulation of Delta-6 desaturase gene transcription
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Endocrineadrenal gland   highly
    Nervousbraindiencephalonamygdala  
    Reproductivemale systemprostate  highly
     male systemtestis  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    N terminal cytochrome b5-like domain and a C terminal multiple membrane spanning desaturase portion (both of which are characterized by conserved histidine motifs)
    conjugated HemoP
    HOMOLOGY
    interspecies ortholog to murine Fads2
    homolog to C.elegans fat-3
    intraspecies paralog to FADS1
    paralog to FADS3
    Homologene
    FAMILY
  • member of the fatty acid desaturase (FADS) gene family
  • cytochrome B5 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • regulating unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain
  • desaturating fatty acids 18:2(n-6) and 18:3(n-3) to form 20:4(n-6) (arachidonic acid) and 22:6(n-3) (docosahexaenoic acid)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid desaturation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by SREBP-1c
    repressed by HUFA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS