Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FADS1 contributors: - updated : 12-07-2006
HGNC name fatty acid desaturase 1
HGNC id 3574
Location 11q12.2-q13.1      Physical location : 61.567.102 - 61.584.529
Synonym name lineoyl CoA desaturase (delta 5 desaturase)-like 1
Synonym symbol(s) LLCDL1, TU12, D5D, FADSD5, FADS6, FLJ38956, FLJ90273
EC.number 1.14.99.25
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text component of a cluster of fatty acid desaturase
STRUCTURE 17.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - FEN1 - FADS1 - FADS2 - FADS3 - VMD2 - FTH1 - qter
Authors Marquardt (00)
regionally located tightly linked to FADS1 in opposite orientation
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 pancreas    
Nervousbrain    
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
Respiratorylung    
Skin/Tegumentskin   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal cytochrome b5-like domain
  • three histidine-rich region
  • a C terminal multiple membrane spanning desaturase portion
  • two membrane spanning domains
  • conjugated HemoP
    HOMOLOGY
    intraspecies paralog to FADS2
    paralog to FADS3
    Homologene
    FAMILY
  • member of the fatty acid desaturase (FADS) gene family, cytochrome B5 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • regulating unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain
  • catalyzing production of polyenoic fatty acids such as arachidonic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid desaturation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS