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FLASH GENE
Symbol FABP7 contributors: mct - updated : 17-02-2017
HGNC name fatty acid binding protein 7, brain
HGNC id 3562
Location 6q22.31      Physical location : 123.100.645 - 123.105.216
Synonym name
  • brain lipid binding protein
  • mammary-derived growth inhibitor related
  • Synonym symbol(s) BBPFA, B-FABP, BLBP, MRG, DKFZp547J2313
    DNA
    TYPE functioning gene
    STRUCTURE 34.88 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    C6orf61 6q22.31 chromosome 6 open reading frame 61 ASF1A 6q22.32 ASF1 anti-silencing function 1 homolog A (S. cerevisiae) MCMDC1 6q22.31 minichromosome maintenance deficient domain containing 1 C6orf60 6q22.31 chromosome 6 open reading frame 60 MAN1A1 6q22 mannosidase, alpha, class 1A, member 1 C6orf170 6q22.32 chromosome 6 open reading frame 170 GJA1 6q22.3 gap junction protein, alpha 1, 43kDa (connexin 43) LOC260339 6q22.32 processed pseudogene mtTFA 3 LOC391966 6 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) LOC391967 6 similar to 60S ribosomal protein L23a HSF2 6q22.33 heat shock transcription factor 2 TDE2 6q22.32 tumor differentially expressed 2 PKIB 6q22.32 protein kinase (cAMP-dependent, catalytic) inhibitor beta FABP7 6q22-q23 fatty acid binding protein 7, brain SMPDL3A 6q22.32 sphingomyelin phosphodiesterase, acid-like 3A C6orf213 6q22.32 chromosome 6 open reading frame 213 TRDN 6q22-q23 triadin TCBA1 6q21-q22 T-cell lymphoma breakpoint associated target 1 IBRDC1 6q22.33 IBR domain containing 1 TPD52L1 6q22-q23 tumor protein D52-like 1 C6orf74 6q13-q24.3 chromosome 6 open reading frame 74 LOC256096 6q22.33 hypothetical LOC256096 HEY2 6q22.2-q22.33 hairy/enhancer-of-split related with YRPW motif 2 NCOA7 6q22.33 nuclear receptor coactivator 7 HINT3 6q22.33 histidine triad nucleotide binding protein 3 C6orf75 6q11.1-q22.33 chromosome 6 open reading frame 75 LOC391968 6 similar to PPP1R14B protein LOC389426 6 LOC389426 LOC391969 6 similar to ribosomal protein S4, X-linked
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1047 - 132 - 2014 25114248
    4 - 788 - 128 - 2014 25114248
    2 - 4198 - 97 - 2014 25114248
    3 - 2382 - 166 - 2014 25114248
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Urinarykidney    
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    Nervousglia Homo sapiens
    Visualcone photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • repeated structure, topology beta barrel and remarkable structural signature
  • HOMOLOGY
    interspecies homolog to murine Fabp7
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be playing roles in fatty acid uptake, transport, and metabolism
  • involved in cell proliferation and invasion and may be associated with tumor progression in melanoma
  • may have a role in pulmonary development and in the pathogenesis of congenital cystic adenomatoid malformation
  • may function as a tumor progression gene
  • role in differentiation and/or proliferation of glial cells through regulation of lipid metabolism and/or signaling
  • is likely involved in the proliferation of astrocytes by controlling cellular fatty acid homeostasis
  • FABP7 and FABP5 are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation
  • FABP7 controls lipid raft function through the regulation of CAV1 expression and is involved in the response of astrocytes to the external stimuli
  • astrocytic FABP7 is important for dendritic arbor growth, neuronal excitatory synapse formation, and synaptic transmission
  • might play an important role in maintaining retinal vasculature
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FABP7 is a direct target of repression by NR1D1
  • lack of NR1D1 increased ARNTL, NPAS2, CLOCK, and FABP7 expression, confirming the direct regulation of these genes by NR1D1 also in the brain
  • cell & other
    REGULATION
    activated by PAX6 (FABP7 promoter activity is upregulated by PAX6)
    induced by NOTCH1 and RELN
    Other regulated by PKC and the MAPK/ERK1/2 pathway through independent mechanisms in melanoma cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in fetal CCAM (congenital cystic adenomatoid malformation) compared with fetal lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can be used as a potential diagnostic biomarker of early-stage melanoma systemic spreading in blood
  • Therapy target
    ANIMAL & CELL MODELS
  • Fabp7-deficient mice and transgenic flies that express the FABP7.T61M missense mutation in astrocytes show fragmented sleep
  • Fabp7-/- mice have significantly decreased retinal venular caliber retinal arteriolar fractal dimension compared with WT littermates