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FLASH GENE
Symbol FABP5 contributors: mct - updated : 09-02-2015
HGNC name fatty acid binding protein 5 (psoriasis-associated)
HGNC id 3560
Location 8q21.13      Physical location : 82.192.784 - 82.197.008
Synonym name
  • fatty acid-binding protein 5
  • psoriasis-associated fatty acid-binding protein homolog
  • Synonym symbol(s) EFABP, PAFAB, MAL1, E-FABP, PA-FABP
    DNA
    TYPE functioning gene
    STRUCTURE 4.22 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 662 - 135 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     pharynx   highly
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systemuterus  highly
     male systemprostate  moderately
    Respiratorylung   highly
     respiratory tractlarynx   
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectiveadipose  highly Homo sapiens
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text trabecular meshwork
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Fabp5 (80.0pc)
    homolog to rattus Fabp5 (80.7pc)
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in keratinocyte differentiation
  • transporting endocannabinoid anandalide arichidonoyl ethanolamide from the plasma membrane to subcellular fatty acid amide hydrolase, which hydrolyzes and inactivates it (Kaczocha 2009)
  • FABP7 and FABP5 are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation
  • FABP4/5 is potentially novel targets for the modulation of energy homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEPTIN11 associated with caveolae in mature adipocytes and interacted with both CAV1 and the intracellular fatty acid chaperone, fatty acid binding protein 5 (FABP5)
  • cell & other
  • fatty acid binding protein
  • REGULATION
    Other up-regulated by NR4A2 (Volakakis 2009)
    DHA can induce nuclear translocation of FABP5 (Volakakis 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    ubiquitous overexpression in endometrial cancers (Li 2008)
    tumoral     --over  
    upregulated in breast cancer (Li 2007)
    tumoral     --low  
    down-regulation of FABP5 is associated with metastasis of squamous cell carcinoma of the oral tongue (Uma 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deficient for both FABP4 and FABP5 (FABP4/5 DKO mice) exhibited defective uptake of fatty acid (FA) with compensatory up-regulation of glucose consumption in these tissues during fasting