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FLASH GENE
Symbol FABP2 contributors: mct - updated : 13-07-2017
HGNC name fatty acid binding protein 2, intestinal
HGNC id 3556
Location 4q26      Physical location : 120.238.405 - 120.243.316
Synonym name intestinal-type fatty acid-binding protein
Synonym symbol(s) FABPI, I-FABP, MGC133132, IFABP
DNA
TYPE functioning gene
STRUCTURE 4.91 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure p300-binding site in the promoter influencing transcriptional activity, body composition and plasma lipid levels
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2271 - 132 - 2017 28232029
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
digestivesmall intestineepithelial cell  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • repeated structure
  • topology beta barrel and remarkable structural signature
  • HOMOLOGY
    interspecies homolog to murine fabp2
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a role in intracellular transport of long-chain fatty acids and their acyl-coa esters
  • probably involved in triglyceride-rich lipoprotein synthesis
  • FABP1, FABP2 display differences in localization, regulation and developmental pattern
  • with ACACA are both key factors of lipogenesis and transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific drug-FABP1, FABP2 complexes can interact with PPARA to effect nuclear accumulation of FABP1, FABP2 and Nuclear hormone receptors (NHRs) activation
  • cell & other
    REGULATION
    induced by EGF
    Other regulated by HNF4A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Abetalipoproteinemia (ABL)
    Susceptibility
  • to transient ischemic attacks and non-cardioembolic infarction at younger onset
  • to insulin resistance
  • to type 2 diabetes (T2DM)
  • Variant & Polymorphism SNP
  • T54 allele appears to be a genetic susceptibility marker for transient ischemic attacks and non-cardioembolic infarction at younger onset
  • association between insulin resistance and homozygosity or heterozygosity for the threonine-encoding allele among Pima Indians in Arizona
  • rs11724758AA in the fatty-acid-binding protein 2 (FABP2) gene were associated with T2DM
  • Candidate gene
    Marker
  • is a valid serologic biomarker for early diagnosis in necrotizing enterocolitis (NEC) for the premature neonates with a moderate accuracy
  • Therapy target
    ANIMAL & CELL MODELS