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FLASH GENE
Symbol FABP1 contributors: mct - updated : 13-07-2017
HGNC name fatty acid binding protein 1, liver
HGNC id 3555
Location 2p11.2      Physical location : 88.422.509 - 88.427.578
Synonym symbol(s) FABL, LFABP, FABPL
DNA
TYPE functioning gene
STRUCTURE 5.15 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC115281 2p11.2 similar to Ig kappa variable region MGC4677 2p11.2 hypothetical protein MGC4677 LOC388972 2 similar to anaphase-promoting complex 1 (meiotic checkpoint regulator) LOC388973 2 similar to plasminogen-like LOC388974 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 LOC388975 2 similar to WW domain binding protein 1 LOC344165 2p11.2 similar to anaphase-promoting complex 1 (meiotic checkpoint regulator) LOC51315 2p11.2 hypothetical protein LOC51315 SMYD1 2p11.1 SET and MYND domain containing 1 FABP1 2p12-p11.2 fatty acid binding protein 1, liver FLJ10916 2p11.2 hypothetical protein FLJ10916 MRPL45P1 2p11.2 hypothetical protein FLJ10916 LOC344167 2p11.2 similar to FoxI1c protein FLJ25369 2p11.2 hypothetical protein FLJ25369 EIF2AK3 2p12 eukaryotic translation initiation factor 2-alpha kinase 3 RPIA 2p11.1 ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase) LOC388976 2 similar to protein that is immuno-reactive with anti-PTH polyclonal antibodies IGKC 2p12 immunoglobulin kappa constant IGKJ5 2p11.2 immunoglobulin kappa joining 5 IGKJ4 2p11.2 immunoglobulin kappa joining 4 IGKJ3 2p11.2 immunoglobulin kappa joining 3 IGKJ2 2p11.2 immunoglobulin kappa joining 2 IGKJ1 2p11.2 immunoglobulin kappa joining 1 IGKV4-1 2p11.2 immunoglobulin kappa variable 4-1 IGKV5-2 2p11.2 immunoglobulin kappa variable 5-2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 598 14.2 127 - 2016 26919097
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly Homo sapiens
 liver   highly Homo sapiens
Lymphoid/Immunespleen    
Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
repeated structure
secondary structure beta barrel
HOMOLOGY
Homologene
FAMILY
  • fatty-acid binding protein (FABP) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • predominantly present in the cytoplasm and to a lesser extent in the nucleus
  • however, a significant portion has also been detected in fractions containing different organelles
  • basic FUNCTION
  • involved in intracellular lipid transport
  • having a significant role in oxidative stress
  • facilitates the cellular uptake, transport and metabolism of fatty acids and is also involved in the regulation of gene expressions and cell differentiation
  • modulates the function of peroxisomal lipid-metabolizing enzymes
  • FABP1, FABP2 display differences in localization, regulation and developmental pattern
  • participates in cellular long-chain fatty acid trafficking and regulation of lipid metabolism and changes in FABP1 are associated with an increased risk for type 2 diabetes, cardiovascular disease (CVD), and metabolic syndromes
  • is an indirect antioxidant protein essential for sequestering free fatty acid and its impairment could contribute to in the pathogenesis of alcoholic liver disease (ALD)
  • provides likely a signaling path to HNF4A activation in the nucleus
  • plays a pivotal role during intracellular bacterial/viral infections by reducing inflammation and the adverse effects of starvation (energy deficiency)
  • FABP1 and SCP2 facilitate the preferential movement of HDL-associated cholesteryl esters (HDL-CEs) to bile for final elimination
  • is a liver-specific fatty acid-binding protein (FABP) that plays important roles in intracellular lipid metabolism in the liver
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • free fatty acids and their coenzyme
  • bilirubin
  • FABP1 is a candidate PDX1 target, and PDX1 regulated repression of FABP1 promoter activity in intestinal cells is consistent with the reduced abundance of FABP1 protein in the proximal duodenum where PDX1 is most abundant
  • HNF4A regulates liver type fatty acid binding protein (FABP1) gene expression
  • specific drug-FABP1, FABP2 complexes can interact with PPARA to effect nuclear accumulation of FABP1, FABP2 and Nuclear hormone receptors (NHRs) activation
  • FABP1 binds and modulates the action of many molecules such as fatty acids, heme, and other metalloporphyrins
  • FABP1 not only is the most prominent endocannabinoid and cannabinoid binding protein but also impacts hepatic endocannabinoid levels
  • cell & other
    REGULATION
    induced by by clofibrate
    Other is regulated by liver-enriched transcription factors FOXA2 and CEBPA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    associated with poorer survival in acetaminophen-induced acute liver failure
    constitutional     --over  
    of circulating CDH5 and FABP1 in association with drug-induced liver injury
    constitutional     --over  
    associated with an increased risk of cardiovascular disease (CVD) and metabolic syndromes
    constitutional     --other  
    dysregulation may contribute to alterations in lipid homeostasis during early-stage alcoholic liver
    constitutional     --low  
    in Abetalipoproteinemia (ABL)
    Susceptibility
  • to altered body mass index (BMI), clinical dyslipidemias (elevated plasma triglycerides and LDL cholesterol), atherothrombotic cerebral infarction, and non-alcoholic fatty liver disease (NAFLD)
  • to variation of Serum Triglyceride (TG) Levels
  • Variant & Polymorphism SNP
  • FABP1 T94A variant is associated with altered body mass index (BMI), clinical dyslipidemias (elevated plasma triglycerides and LDL cholesterol), atherothrombotic cerebral infarction, and non-alcoholic fatty liver disease (NAFLD)
  • rs2919872 A allele reduces the transcriptional activity of FABP1 promoter, and thereby may link FABP1 gene variation to TG level
  • Candidate gene
    Marker
  • is a promising biomarker of several kidney diseases
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneoushypertension 
    in the proximal tubules may be a novel therapeutic target for salt-sensitive hypertension (SSHT)
    ANIMAL & CELL MODELS
  • silencing of Fabp1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease