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FLASH GENE

Symbol

FABP1

contributors: mct - updated : 13-07-2017

HGNC name	fatty acid binding protein 1, liver
HGNC id	3555

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p11.2      Physical location : 88.422.509 - 88.427.578
Synonym symbol(s)	FABL, LFABP, FABPL

DNA

TYPE	functioning gene
STRUCTURE	5.15 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001443 4 - 598 NP_001434 14.2 127 - 2016 26919097

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly Homo sapiens   liver       highly Homo sapiens Lymphoid/Immune spleen         Urinary kidney tubule convoluted tubule proximal tubule highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

repeated structure

secondary structure

beta barrel

HOMOLOGY

Homologene

FAMILY

fatty-acid binding protein (FABP) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,peroxisome
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
text	predominantly present in the cytoplasm and to a lesser extent in the nucleus
	however, a significant portion has also been detected in fractions containing different organelles

basic FUNCTION	involved in intracellular lipid transport
	having a significant role in oxidative stress
	facilitates the cellular uptake, transport and metabolism of fatty acids and is also involved in the regulation of gene expressions and cell differentiation
	modulates the function of peroxisomal lipid-metabolizing enzymes
	FABP1, FABP2 display differences in localization, regulation and developmental pattern
	participates in cellular long-chain fatty acid trafficking and regulation of lipid metabolism and changes in FABP1 are associated with an increased risk for type 2 diabetes, cardiovascular disease (CVD), and metabolic syndromes
	is an indirect antioxidant protein essential for sequestering free fatty acid and its impairment could contribute to in the pathogenesis of alcoholic liver disease (ALD)
	provides likely a signaling path to HNF4A activation in the nucleus
	plays a pivotal role during intracellular bacterial/viral infections by reducing inflammation and the adverse effects of starvation (energy deficiency)
	FABP1 and SCP2 facilitate the preferential movement of HDL-associated cholesteryl esters (HDL-CEs) to bile for final elimination
	is a liver-specific fatty acid-binding protein (FABP) that plays important roles in intracellular lipid metabolism in the liver

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	free fatty acids and their coenzyme
	bilirubin
	FABP1 is a candidate PDX1 target, and PDX1 regulated repression of FABP1 promoter activity in intestinal cells is consistent with the reduced abundance of FABP1 protein in the proximal duodenum where PDX1 is most abundant
	HNF4A regulates liver type fatty acid binding protein (FABP1) gene expression
	specific drug-FABP1, FABP2 complexes can interact with PPARA to effect nuclear accumulation of FABP1, FABP2 and Nuclear hormone receptors (NHRs) activation
	FABP1 binds and modulates the action of many molecules such as fatty acids, heme, and other metalloporphyrins
	FABP1 not only is the most prominent endocannabinoid and cannabinoid binding protein but also impacts hepatic endocannabinoid levels

cell & other

REGULATION

induced by

by clofibrate

Other

is regulated by liver-enriched transcription factors FOXA2 and CEBPA

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   associated with poorer survival in acetaminophen-induced acute liver failure constitutional     --over   of circulating CDH5 and FABP1 in association with drug-induced liver injury constitutional     --over   associated with an increased risk of cardiovascular disease (CVD) and metabolic syndromes constitutional     --other   dysregulation may contribute to alterations in lipid homeostasis during early-stage alcoholic liver constitutional     --low   in Abetalipoproteinemia (ABL)

Susceptibility

to altered body mass index (BMI), clinical dyslipidemias (elevated plasma triglycerides and LDL cholesterol), atherothrombotic cerebral infarction, and non-alcoholic fatty liver disease (NAFLD) to variation of Serum Triglyceride (TG) Levels

Variant & Polymorphism SNP	FABP1 T94A variant is associated with altered body mass index (BMI), clinical dyslipidemias (elevated plasma triglycerides and LDL cholesterol), atherothrombotic cerebral infarction, and non-alcoholic fatty liver disease (NAFLD)
	rs2919872 A allele reduces the transcriptional activity of FABP1 promoter, and thereby may link FABP1 gene variation to TG level

Candidate gene
Marker	is a promising biomarker of several kidney diseases
Therapy target
	System Type Disorder Pubmed miscelleaneous hypertension   in the proximal tubules may be a novel therapeutic target for salt-sensitive hypertension (SSHT)

ANIMAL & CELL MODELS

silencing of Fabp1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease