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FLASH GENE
Symbol F7 contributors: mct - updated : 09-09-2014
HGNC name coagulation factor VII (serum prothrombin conversion accelerator)
HGNC id 3544
Corresponding disease
F7 factor VII deficiency
Location 13q34      Physical location : 113.760.104 - 113.774.994
Genatlas name proconvertin
Synonym name serum prothrombin conversion accelerator
Synonym symbol(s) FA7, SPCA
EC.number 3.4.21.21
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   HRE
motif repetitive sequence
text structure
  • oestrogene responsive element
  • 5' flanking region, the hepatic nuclear factor 4 binding region (-77 to -47) and the nuclear hormone response region (-237 to -200)
    • MAPPING cloned Y linked N status confirmed
    regionally located 2.8 kb upstream F10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2478 51 466 - Hagen
    - splicing 2412 - 414 - Hagen
    - splicing 2462 - 466 - Hagen
    alternative exon 1b
    - - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus GLA domain followed by two cysteine-rich domains, highly homologous to EGF,
  • a C terminal catalytic (serine protease) domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to murine F7
    Homologene
    FAMILY peptidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text plasma specific
    basic FUNCTION
  • coagulation factor VII, vitamin K-dependent, initiating the extrinsic pathway of blood coagulation
  • F7 and PROC are phosphatidic acid-binding proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    extrinsic pathway of blood coagulation
    a component
  • complexing with cofactor F3 or tissue factor
  • heterodimer of a light chain and a heavy chain linked by a disulfide bond
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating FIX, FX
  • binds to the endothelial cell protein C receptor (PROCR) on the vascular endothelium and F7 binding to PROCR on the endothelium facilitates the transport of F7 from circulation to extravascular tissues
    • cell & other
    REGULATION
    Other the active form being generated by the cleavage of Arg152-Ile153 peptide bond by FIXa,Fxa,FXIIa,FII,leading to two chains heavy (catalytic),light,held together by a disulfide bond
    ASSOCIATED DISORDERS
    corresponding disease(s) F7
    related resource Factor VII Mutation Database
    Susceptibility to myocardial infarction
    Variant & Polymorphism some F7 genotypes maybe a protective factor
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS