basic FUNCTION
| initiating blood coagulation by complexing with FVII or FVIIa |
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participate in hemostatic and inflammatory processes |
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plays a role in normal hemostasis by initiating |
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the cell-surface assembly and propagation of the coagulation protease cascade |
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prime initiator of blood coagulation playing a critical role in thrombosis and hemostasis |
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has an important role in the initiation of coagulation and in the increase in thrombin activity at the site of inflammation (Isada 2010) |
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protect cardiomyocytes against TNF-induced apoptosis via activation of specific signaling pathways, and up-regulation of anti-apoptotic members of the BCL2 protein family |
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functional, procoagulant F3 is required for the generation of thrombin, which in turn activates F2R to promote phosphorylation of the cytoplasmic domain of F3 in enterocytes |
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F3-induced endothelial cell (EC) CCL2 release contributes to neovessel formation |
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in endothelial cell, F3 forms a complex with AKT1 activating RAF1/ERK and ETS1 signaling induces microvessel formation |
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membrane surface F3 mediates airway epithelial basal cell attachment, which maintains cell survival and mitotic potential |
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F3 is chaperoned by PDIA2 to the coronary smooth muscle cells (HVSMC) membrane and to the cell migratory front |