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FLASH GENE
Symbol F3 contributors: mct/npt - updated : 24-10-2013
HGNC name coagulation factor III (thromboplastin, tissue factor)
HGNC id 3541
Location 1p21.3      Physical location : 94.994.731 - 95.007.413
Synonym name
  • thromboplastin
  • tissue factor
  • CD142 antigen
  • Synonym symbol(s) HTF, CD142, TF, TFA
    DNA
    TYPE functioning gene
    STRUCTURE 12.68 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC339526 1p22.1 similar to hypothetical protein FLJ20481 LOC126598 1p22.1 similar to template acyivating factor-I alpha LOC284697 1p22.1 similar to agCP5986 KIAA1107 1p22.1 KIAA1107 protein LOC388649 1 similar to 1700028K03 protein GLMN 1p22.1 glomulin, FKBP associated protein FLJ13150 1p22.1 hypothetical protein FLJ13150 GFI1 1p22 growth factor independent 1 EVI5 1p22 ecotropic viral integration site 5 RPL5 1p22.1-p21.3 ribosomal protein L5 LOC388650 1 similar to RIKEN cDNA 2900024C23 M96 1p22.1 likely ortholog of mouse metal response element binding transcription factor 2 CGI-100 1pter-q31.3 CGI-100 protein NY-SAR-41 1p22.1 sarcoma antigen NY-SAR-41 DR1 1p22.1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) FLJ20275 BCAR3 1p22.1 breast cancer anti-estrogen resistance 3 LOC388651 1 LOC388651 HSU15552 1p22.1 acidic 82 kDa protein mRNA GCLM 1p22.1 glutamate-cysteine ligase, modifier subunit ABCA4 1p22.1 ATP-binding cassette, sub-family A (ABC1), member 4 PARG1 1p22.1 PTPL1-associated RhoGAP 1 LOC391057 1 similar to uracil DNA glycosylase ABCD3 1p22.1-p21.3 ATP-binding cassette, sub-family D (ALD), member 3 F3 1p22.1-p21 coagulation factor III (thromboplastin, tissue factor) MGC45474 1p22.1 hypothetical protein MGC45474 CNN3 1p21 calponin 3, acidic MGC19780 1p22.1 hypothetical protein MGC19780 FLJ31842 1p22.1 hypothetical protein FLJ31842 RWDD3 1p22.1 RWD domain containing 3 LOC388652 1 LOC388652 LOC284555 1p22.1 hypothetical LOC284555 LOC284556 1p22.1 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati PTBP2 1p22.11-p21.3 polypyrimidine tract binding protein 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2393 47 295 - 2013 23801760
    5 - 2233 - 238 - 2013 23801760
  • alternative exon 1A-tissue factor
  • alternatively spliced (as)TF--a protein that lacks a transmembrane domain and can thus be secreted in a soluble form
  • high-level expression, preferentially in tumor cells, may have utility in the diagnosis and staging of a variety of solid tumors
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestivemouthtongue  highly
    Respiratorylung   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumcardiacmyocardium  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Cardiovascularendothelial cell
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal extracellular region
  • two fibronectin-3-like domains
  • a transmembrane (TM) segment
  • a short C terminal cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • tissue factor family
  • CATEGORY immunity/defense , regulatory , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • initiating blood coagulation by complexing with FVII or FVIIa
  • participate in hemostatic and inflammatory processes
  • plays a role in normal hemostasis by initiating
  • the cell-surface assembly and propagation of the coagulation protease cascade
  • prime initiator of blood coagulation playing a critical role in thrombosis and hemostasis
  • has an important role in the initiation of coagulation and in the increase in thrombin activity at the site of inflammation (Isada 2010)
  • protect cardiomyocytes against TNF-induced apoptosis via activation of specific signaling pathways, and up-regulation of anti-apoptotic members of the BCL2 protein family
  • functional, procoagulant F3 is required for the generation of thrombin, which in turn activates F2R to promote phosphorylation of the cytoplasmic domain of F3 in enterocytes
  • F3-induced endothelial cell (EC) CCL2 release contributes to neovessel formation
  • in endothelial cell, F3 forms a complex with AKT1 activating RAF1/ERK and ETS1 signaling induces microvessel formation
  • membrane surface F3 mediates airway epithelial basal cell attachment, which maintains cell survival and mitotic potential
  • F3 is chaperoned by PDIA2 to the coronary smooth muscle cells (HVSMC) membrane and to the cell migratory front
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text component of cellular immune response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • F7 binding
  • procoagulant role of PROC pathway may have important implications for the regulation of F3- and TFPI-dependent biologic responses and for fine tuning of the hemostatic balance in the vascular system
  • F3 regulates CCL2 production in endothelial cells, and mediates the angiogenic effect of F3 by recruiting smooth muscle cells toward endothelial cells and facilitates the maturation of newly formed microvessels
  • BMP2 as a novel inhibitor of F3 expression in lipopolysaccharide (LPS)-activated human monocytes
  • mediates signalling through coagulation proteases that activate the G-protein-coupled receptors F2R and F2RL1
  • binding to its ligand F7 induces activation of F2RL1 and this event is thought to considerably influence atherosclerosis and tumor angiogenesis
  • participates in protease-activated receptor F2R and F2RL1 activation
  • inverse expression pattern of CDKN1B and F3, but also a direct regulatory link between the two proteins
  • ER-stress protein-disulphide isomerase family A member 2 (PDIA2) regulates tissue factor (F3)
  • TICAM1 regulated foam cell formation via regulation of the expression levels of CCL2, F3, OLR1
  • cell & other
    REGULATION
    induced by inflammatory mediators interleukin 1,TNFs,endotoxin in the cellular immune response
    CD40L (TNFSF5) in endothelial cells,under mediation of EGR1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of monocytic F3 expression in advanced liver cirrhosis
    tumoral     --over  
    in breast cancer
    Susceptibility
  • to venous thromboembolism
  • to adult-onset asthma
  • Variant & Polymorphism SNP association between the functional polymorphism (603A> G) in the promoter and adult-onset asthma (Isada 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS