Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

F3

contributors: mct/npt - updated : 24-10-2013

HGNC name	coagulation factor III (thromboplastin, tissue factor)
HGNC id	3541

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p21.3      Physical location : 94.994.731 - 95.007.413
Synonym name	thromboplastin
	tissue factor
	CD142 antigen
Synonym symbol(s)	HTF, CD142, TF, TFA

DNA

TYPE	functioning gene
STRUCTURE	12.68 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001993 6 - 2393 NP_001984 47 295 - 2013 23801760 NM_001178096 5 - 2233 NP_001171567 - 238 - 2013 23801760 alternative exon 1A-tissue factor alternatively spliced (as)TF--a protein that lacks a transmembrane domain and can thus be secreted in a soluble form high-level expression, preferentially in tumor cells, may have utility in the diagnosis and staging of a variety of solid tumors

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Digestive mouth tongue     highly Respiratory lung       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Muscular striatum cardiac myocardium   Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Cardiovascular endothelial cell Muscular myocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal extracellular region
	two fibronectin-3-like domains
	a transmembrane (TM) segment
	a short C terminal cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

tissue factor family

CATEGORY

immunity/defense , regulatory , receptor membrane

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	initiating blood coagulation by complexing with FVII or FVIIa
	participate in hemostatic and inflammatory processes
	plays a role in normal hemostasis by initiating
	the cell-surface assembly and propagation of the coagulation protease cascade
	prime initiator of blood coagulation playing a critical role in thrombosis and hemostasis
	has an important role in the initiation of coagulation and in the increase in thrombin activity at the site of inflammation (Isada 2010)
	protect cardiomyocytes against TNF-induced apoptosis via activation of specific signaling pathways, and up-regulation of anti-apoptotic members of the BCL2 protein family
	functional, procoagulant F3 is required for the generation of thrombin, which in turn activates F2R to promote phosphorylation of the cytoplasmic domain of F3 in enterocytes
	F3-induced endothelial cell (EC) CCL2 release contributes to neovessel formation
	in endothelial cell, F3 forms a complex with AKT1 activating RAF1/ERK and ETS1 signaling induces microvessel formation
	membrane surface F3 mediates airway epithelial basal cell attachment, which maintains cell survival and mitotic potential
	F3 is chaperoned by PDIA2 to the coronary smooth muscle cells (HVSMC) membrane and to the cell migratory front

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

coagulation/hemostasis

text	component of cellular immune response

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	F7 binding
	procoagulant role of PROC pathway may have important implications for the regulation of F3- and TFPI-dependent biologic responses and for fine tuning of the hemostatic balance in the vascular system
	F3 regulates CCL2 production in endothelial cells, and mediates the angiogenic effect of F3 by recruiting smooth muscle cells toward endothelial cells and facilitates the maturation of newly formed microvessels
	BMP2 as a novel inhibitor of F3 expression in lipopolysaccharide (LPS)-activated human monocytes
	mediates signalling through coagulation proteases that activate the G-protein-coupled receptors F2R and F2RL1
	binding to its ligand F7 induces activation of F2RL1 and this event is thought to considerably influence atherosclerosis and tumor angiogenesis
	participates in protease-activated receptor F2R and F2RL1 activation
	inverse expression pattern of CDKN1B and F3, but also a direct regulatory link between the two proteins
	ER-stress protein-disulphide isomerase family A member 2 (PDIA2) regulates tissue factor (F3)
	TICAM1 regulated foam cell formation via regulation of the expression levels of CCL2, F3, OLR1

cell & other

REGULATION

induced by	inflammatory mediators interleukin 1,TNFs,endotoxin in the cellular immune response
		CD40L (TNFSF5) in endothelial cells,under mediation of EGR1

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   of monocytic F3 expression in advanced liver cirrhosis tumoral     --over   in breast cancer

Susceptibility

to venous thromboembolism to adult-onset asthma

Variant & Polymorphism SNP	association between the functional polymorphism (603A> G) in the promoter and adult-onset asthma (Isada 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS