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FLASH GENE
Symbol F11R contributors: mct - updated : 16-12-2014
HGNC name F11 receptor
HGNC id 14685
Location 1q23.3      Physical location : 160.965.001 - 160.991.133
Synonym name
  • platelet adhesion molecule PAM-1
  • platelet F11 receptor
  • junctional adhesion molecule 1
  • junctional adhesion molecule A
  • CD321 antigen
  • Synonym symbol(s) JAM, JAM1, PAM-1, JAM-1, KAT, JCAM, CD321, JAMA, CD321
    DNA
    TYPE functioning gene
    STRUCTURE 26.13 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site
    text structure
  • P1 is a TATA-less promoter containing an initiator element, multiple transcription start sites, several GC and CCAAT boxes, and GATA, NF-kappaB and ets consensus sequences
  • promoter P2, located upstream of P1, contains a TATA box, GC boxes, a CCAAT box and GATA and ets consensus sequences
  • MAPPING cloned Y linked N status provisional
    Physical map
    CD84 1q22-q23 CD84 antigen (leukocyte antigen) SLAMF1 1q21.3-1q23.2 signaling lymphocytic activation molecule family member 1 CD48 1q23 CD48 antigen (B-cell membrane protein) SLAMF7 1q23.1-q24.1 SLAM family member 7 LY9 1q21.3-q22 lymphocyte antigen 9 CD244 1q23.1 CD244 natural killer cell receptor 2B4 ITLN1 1q21.3 intelectin 1 (galactofuranose binding) LOC284679 1q23.1 similar to spermine synthase; spermidine aminopropyltransferase ITLN2 1q22-q23.5 intelectin 2 F11R 1q21.2-q21.3 F11 receptor USF1 1q22-q23 upstream transcription factor 1 LOC388708 1 similar to KAT protein LOC257106 1q23.1 hypothetical protein LOC257106 LNIR MGC33338 1q23.1 hypothetical protein MGC33338 PFDN2 1q23.1 prefoldin 2 NIT1 1q21-q22 nitrilase 1 DEDD 1q21.3 death effector domain containing HSPC155 1q23.1 hypothetical protein HSPC155 USP21 1q22 ubiquitin specific protease 21 PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) FCER1G 1q23 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide APOA2 1q21-q23 apolipoprotein A-II FLJ12770 1q23.1 hypothetical protein FLJ12770 NR1I3 1q23.1 nuclear receptor subfamily 1, group I, member 3 MPZ 1q22 myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)
    RNA
    TRANSCRIPTS type messenger
    text multiple transcripts, with two alternative promoters, P1 and P2
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4830 - 299 - 2006 16418218
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiensAdult
    Digestiveesophagus   highly
     intestinelarge intestinecolon  
     pharynx   highly
    Lymphoid/Immunelymphatic vessel     Homo sapiensAdult
     spleen    
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    Cardiovascularendothelial cell Homo sapiensAdult
    cell lineage hematopoietic cells of cell lineages
    cell lines breast, colon, lung carcinoma cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal signal peptide
  • two potential N glycosylation sites
  • an extracellular domain containing two extracellular IgV or C2-type loops
  • a short C terminal tail with a PDZ domain
  • HOMOLOGY
    interspecies homolog to murine Jcam1
    Homologene
    FAMILY
  • JAM family
  • CATEGORY adhesion , immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,nuclear envelope
    text integral transmembrane protein of tight junction, colocalizing with F actin at membrane ruffles
    basic FUNCTION
  • regulating the tight junction assembly in epithelia
  • counter-receptor for LFA1 controling transmigration during leukocyte recruitment
  • cell adhesion molecule of the immunoglobulin superfamily involved in platelet adhesion, secretion
  • plays a critical role in the function of endothelial cells and in platelet adhesion to inflamed endothelium
  • having with NKkappa B a function in the initiation of inflammatory thrombosis
  • JAM1, JAM2, JAM3 expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions
  • play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity
  • in addition to the previously reported role of F11R in the initiation of plaque formation, F11R plays also an important role in the subsequent growth of atherosclerotic plaques
  • restricts intestinal epithelial cell (IEC) proliferation in a dimerization-dependent manner, by inhibiting AKT1-dependent CTNNB1 activation
  • unique tight junction (TJ) transmembrane protein that under basal conditions maintains endothelial cell-cell interactions but under inflammatory conditions acts as a leukocyte adhesion molecule
  • potential role in controlling perijunctional actin cytoskeleton in addition to its previously reported role in regulating claudin proteins and small-molecule permeability
  • cell adhesion molecule found on the surface of human platelets
  • key regulator of mesoangioblasts (MABs) extravasation
  • serve a crucial role in the proliferation, differentiation, and tube-like formation of epithelial cells during angiogenesis
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , inflammation
    text platelet aggregation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically and functionally associated with the PDZ domain-containing MLLT4 and PDZGEF2, but not zonula occludens (ZO)-1, in epithelial cells
  • Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-ATP2B4 and CASK-F11R interactions
  • involvement of RHOA and ROCK1 in F11R relocalization
  • associates directly with TJP2 and indirectly with afadin, and this complex, along with RAPGEF2, activates the small GTPase RAP2C
  • regulates epithelial permeability via association with TJP2, afadin, and RAPGEF2 to activate RAP2C and control contraction of the apical cytoskeleton
  • ADAR, but not ADAR2, takes part in the editing of F11R however editing alone is not sufficient for obtaining an elevation in RNA levels
  • plays an important role in non-small cell lung cancer (NSCLC) progression
  • recruits CSK to the integrin-SRC complex in resting platelets
  • cell & other
  • receptor for retrovirus, required for activation NF-kappa B and apoptosis
  • REGULATION
    Other induced during differentiation of THP-1 dendritic cells and is independent of PPAR-gamma and the p38 MAPK pathway (Ogasawara 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS