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FLASH GENE
Symbol F11 contributors: mct/npt - updated : 14-04-2010
HGNC name coagulation factor XI
HGNC id 3529
Corresponding disease
F11 bleeding diathesis, mild, inconstant
Location 4q35.2      Physical location : 187.187.117 - 187.210.835
Synonym name plasma thromboplastin antecedent
Synonym symbol(s) FXI, MGC141891, PTA
EC.number 3.4.21.27
DNA
TYPE functioning gene
STRUCTURE 23.72 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
text structure sequence ACTTTG, required for binding of the transcription factor hepatocyte nuclear factor 4alpha (HNF-4alpha) and for hepatocyte-specific function of F11
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3278 - 625 - White-Adams (2009)
- - 2060 - 571 . platelet, factor XI -
  • lacking exon 5
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • plasma kallikrein subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
    basic FUNCTION
  • triggering the middle phase of the intrinsic pathway of blood coagulation by activating factor IX
  • promotes hemostasis and thrombosis through enhancement of thrombin generation and may play a critical role in the formation of occlusive thrombi in arterial injury models (White-Adams 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer consisting of two identical polypeptide chains linked by disulfide bonds and during activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LRP8 (a platelet receptor for FXI) (White-Adams 2009)
    • cell & other
    REGULATION
    activated by FXIIa producing a serine protease composed of two heavy and two light chains
    FXIIa and thrombin (dimeric structure of FXI is essential for normal proteolytic activation of FXI by FXIIa, thrombin, or FXIa either in solution or on an anionic surface but not for FIX activation by FXIa in solution)(Wu 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) F11
    Susceptibility high levels of F11 representing a risk factor for deep venous thrombosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS