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FLASH GENE
Symbol F10 contributors: mct - updated : 04-04-2013
HGNC name coagulation factor X
HGNC id 3528
Corresponding disease
F10D factor X deficiency
Location 13q34      Physical location : 113.777.112 - 113.803.841
Synonym name
  • Stuart-Prower factor
  • factor Xa
  • prothrombinase
  • Synonym symbol(s) RP11-98F14.9, FX, FXA
    EC.number 3.4.21.6
    DNA
    TYPE functioning gene
    STRUCTURE 26.73 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see COL4A1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1560 - 488 - 1986 3011603
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminus GLA domain
  • a signal peptide, which is necessary for targeting the nascent polypeptide into the endoplasmic reticulum
  • two cysteine-rich domains highly homologous to EGF
  • a C terminal serine protease catalytic domain, cleaved in a two chain protein containing a 17kDa light chain bearing the GLA domain and a 45 kDa heavy chain with the serine protease domain
  • conjugated GlycoP
    isoforms Precursor . zymogen
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • coagulation factor X (Stuart Prower), vitamin K-dependent, converting prothrombin to thrombin in the presence of FVa, Ca2+ and phospholipid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • F5, activated to form the prothrombinase complex
  • inhibits cancer cell migration via LIMK1-mediated cofilin inactivation
  • cell & other
    REGULATION
    activated by through either the contact-activated (intrinsic) pathway and FIXa or the tissue-factor (extrinsic) pathway and FVIIa
    ASSOCIATED DISORDERS
    corresponding disease(s) F10D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by hypomethylation, detected in 82p100 of glioma specimens and in no normal brain tissues, with significant correlation with its protein expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS