basic FUNCTION
| membrane associated protein, responding and participating in reorganization of membrane-cytoplasm interactions |
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cross-linker between the actin cytoskeleton and the membrane |
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allows the local activation of RHOG at the apical pole of epithelial cells by recruiting upstream and downstream regulators of RHOG and both PLEKHG6 and ezrin are required for efficient macropinocytosis |
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involved in microvilli formation and breakdown |
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clustering in an endothelial actin rich docking structure with ICAM1, MSN, VCAM1 |
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membrane-cytoskeletal linker, binding to L1CAM |
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regulating SLC9A3 translocation and activation after Na=-glucose cotransport (when is activated by MAPK14) |
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playing a key role in cell surface structure adhesion, migration, and organization |
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acts as a link between the cell membrane and actin cytoskeleton to integrate cell adhesion-mediated signaling |
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essential roles of SLC9A3R1 and ezrin in intracellular trafficking in epithelial cells (long-range allosteric regulation of SLC9A3R1 by ezrin enables the membrane-cytoskeleton to assemble protein complexes that control cross-talk and regulate the strength and duration of signaling) |
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with moesin function together to promote T cell activation |
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in the vagina, as in other tissues, likely modulates vaginal cell-cell interactions including the changing vaginal cellular interface with the external environment, the regulation of the elasticity of the vagina, and the regulation of microbial and chemical traffic that determine the pH and microbial environment of the vagina |
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is a negative regulator of death receptor-induced apoptosis |
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ezrin and microtubules are important to down-regulate signalling events leading to Erk1/2 activation |
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a crucial function for ezrin, DLG1 and microtubules in the organization of the immune synapse and TCR signal down-regulation |
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cytoskeleton linker protein that is actively involved in the metastatic capacity of cancer cells |
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ERM proteins (Ezrin, Radixin, Moesin) have the ability to organize multiprotein complexes in specific cellular compartments |
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necessary for RAP-induced cell spreading, but not RAP-induced cell adhesion or basal adhesion processes |
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novel function for Ezrin in TERF2IP-induced cell spreading and evidence of a non-redundant role of an ERM family member |
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its function in building and maintaining the apical domain is essential not only for intestinal morphogenesis but also for homeostasis in the mature intestine |
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function in RAP1A-induced cell spreading and evidence of a non-redundant role of an ERM family member |
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is potentially required for the structural plasticity of peripheral astrocyte process |
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regulate cellular survival, adhesion, migration, and invasion and has been identified as 1 of the key components of tumor progression and metastasis |
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ezrin, radixin and moesin are adaptor proteins that link plasma membrane receptors to the actin cytoskeleton |
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membrane cytoskeleton linker, that participates in several functions downstream of the receptor Met in response to HGF stimulation |
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role for EZR in Met receptor stability and activity through its association with the E3 ubiquitin ligase WWP1 |
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EZR and IQGAP1 colocalize in the submembraneous cytoskeleton and in cellular protrusions of human epithelial cells |
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importance of the EZR-mediated connection between plasma membrane and cortex for cellular mechanics and cell morphology |
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BCAR1 and EZR are structural proteins with an important role in signaling pathways and have been shown to promote cancer dissemination |
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in Ovarian cancer, the role of EZR in disease progression is more pronounced than that of BCAR1 |
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supportive role of EZR, RDX, MSN in cortical activities during cytokinesis |
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EZR and MSN play mutually exclusive roles in modulating SELL signalling and shedding to control protrusion dynamics and polarity during monocyte Leukocyte transendothelial migration (TEM) |
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S100P and EZR promote trans-endothelial migration of triple negative breast cancer cells |
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modulates cancer stem cells (CSC) properties in pancreatic cancer |
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cytoskeleton linker protein, is closely linked with the metastatic progression of cancer |
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ERM proteins, EZR, radixin and moesin, assist in the formation and maintenance of specialized plasma membrane structures and membrane vesicle structures |