basic FUNCTION
| participating to normal development of branchial arches, ear, kidney, directly in the modulation of cellular signaling through its phosphatase activity |
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playing a key role in the regulation of genes known to be important for sensory development |
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regulates SHH signaling in embryonic lung, thus ensuring the proper level of proliferation and differentiation along the proximodistal axis of epithelial, mesenchymal and endothelial cells |
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its function is critical for proper coordination of lung epithelial, mesenchymal and vascular development |
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functioning as a crucial regulator of the complex behavior of distal embryonic lung epithelium |
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EYA1 and SIX1 are key transcription factors in initiating the neuronal developmental program, probably by recruiting and interacting with the SWI/SNF chromatin-remodeling complex to specifically mediate NEUROG1 and NEUROD1 transcription |
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regulates tight junction formation in lung distal epithelium |
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is required for cell proliferation and survival during mammalian organogenesis |
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EYA1 enhanced cellular proliferation, inhibited apoptosis, and induced contact-independent growth and CCND1 abundance |
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conserved critical regulator of organ-specific stem cells |
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functional link between EYA1, SIX2, and MYC in driving the expansion and maintenance of the multipotent progenitors during nephrogenesis |
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catalytically active phosphatase EYA1 cooperates with the DNA-binding protein SIX1 to promote gene induction in response to SHH and EYA1/SIX1 together regulate GLI transcriptional activators |
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EYA1 and SIX1 as key components of the SHH transcriptional network in normal development and in oncogenesis |