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FLASH GENE

Symbol

EXOSC10

contributors: mct - updated : 17-09-2018

HGNC name	exosome component 10
HGNC id	9138

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.2      Physical location : 11.126.677 - 11.159.938
Synonym name	autoantigen PM-SCL
	polymyositis/scleroderma autoantigen 2 (100kD)
	autoantigen PM/Scl 2
Synonym symbol(s)	p2, p3, p4, RRP6, PMSCL, Rrp6p, PM-Scl, PMSCL2, PM/Scl-100

DNA

TYPE	functioning gene
STRUCTURE	33.29 kb     24 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002685 24 - 2759 NP_002676 85 860 - 2002 12419256 EXOSC10 variant 2 NM_001001998 25 - 2834 NP_001001998 100 885 - 2002 12419256 EXOSC10 variant 1

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain basal nuclei caudate nucleus       spinal cord         Reproductive female system breast mammary gland       female system placenta       Skeleton appendicular skeleton joint synovia

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic thymocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two potential glycosylation sites
	multiple potential phosphorylation sites
	one 3'-5' exonuclease domain
	one HRDC domain

HOMOLOGY

interspecies

homolog to murine Exosc10

Homologene

FAMILY

CATEGORY

enzyme , RNA associated , antigen

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	required for the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA
	has a 3'-5' exonuclease activity
	although not required for exosome stability, EXOSC10 and EXOSC9 are involved in mRNA degradation, either as essential subunits of a functional exosome complex or as exosome-independent proteins
	may play a more prominent role in processing, as in degradation of coding and noncoding RNA

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)

INTERACTION

DNA

RNA

binding

small molecule

protein	PARN increased TERC levels by deadenylating TERC, thereby limiting its degradation by EXOSC10
	interaction of CELF1 and EXOSC10 was RNA-independent and nucleus specific
	was likely required for CELF1-mediated GJA1 mRNA degradation
	interaction between SMNDC1 and the exosome core is mediated by MTREX and EXOSC10, a catalytic component of the nuclear exosome

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS