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FLASH GENE
Symbol EXOSC10 contributors: mct - updated : 17-09-2018
HGNC name exosome component 10
HGNC id 9138
Location 1p36.2      Physical location : 11.126.677 - 11.159.938
Synonym name
  • autoantigen PM-SCL
  • polymyositis/scleroderma autoantigen 2 (100kD)
  • autoantigen PM/Scl 2
  • Synonym symbol(s) p2, p3, p4, RRP6, PMSCL, Rrp6p, PM-Scl, PMSCL2, PM/Scl-100
    DNA
    TYPE functioning gene
    STRUCTURE 33.29 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 2759 85 860 - 2002 12419256
    EXOSC10 variant 2
    25 - 2834 100 885 - 2002 12419256
    EXOSC10 variant 1
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainbasal nucleicaudate nucleus  
     spinal cord    
    Reproductivefemale systembreastmammary gland  
     female systemplacenta   
    Skeletonappendicular skeletonjointsynovia  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two potential glycosylation sites
  • multiple potential phosphorylation sites
  • one 3'-5' exonuclease domain
  • one HRDC domain
  • HOMOLOGY
    interspecies homolog to murine Exosc10
    Homologene
    FAMILY
    CATEGORY enzyme , RNA associated , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required for the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA
  • has a 3'-5' exonuclease activity
  • although not required for exosome stability, EXOSC10 and EXOSC9 are involved in mRNA degradation, either as essential subunits of a functional exosome complex or as exosome-independent proteins
  • may play a more prominent role in processing, as in degradation of coding and noncoding RNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • PARN increased TERC levels by deadenylating TERC, thereby limiting its degradation by EXOSC10
  • interaction of CELF1 and EXOSC10 was RNA-independent and nucleus specific
  • was likely required for CELF1-mediated GJA1 mRNA degradation
  • interaction between SMNDC1 and the exosome core is mediated by MTREX and EXOSC10, a catalytic component of the nuclear exosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS