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FLASH GENE
Symbol EXOC8 contributors: mct - updated : 22-09-2015
HGNC name exocyst complex component 8
HGNC id 24659
Location 1q42.2      Physical location : 231.468.482 - 231.473.578
Synonym name exocyst complex 84-kDa subunit
Synonym symbol(s) EXO84, SEC84, Exo84p
DNA
TYPE functioning gene
STRUCTURE 5.10 kb     1 Exon(s)
MAPPING cloned Y linked N status confirmed
Map cen - D1S2833 - D1S225 - EXOC8 - D1S251 - D1S2709 - qter
Authors UCSC (2009)
Physical map
FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751 RAB4A 1q42-q43 RAB4A, member RAS oncogene family SPHAR 1q42.11-q42.3 S-phase response (cyclin-related) LOC126731 1q42.13 LOC126731 ACTA1 1q42.13-q42.2 actin, alpha 1, skeletal muscle NUP133 1q42.13 nucleoporin 133kDa ABCB10 1q42 ATP-binding cassette, sub-family B (MDR/TAP), member 10 TAF5L 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa KIAA0133 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC391177 1 similar to HMG-1 LOC388752 1 LOC388752 GALNT2 1q41-q42 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) PGBD5 1q42.13 piggyBac transposable element derived 5 COG2 1q41 component of oligomeric golgi complex 2 AGT 1q42-q43 angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8) CAPN9 1q42.11-q42.3 calpain 9 (nCL-4) FLJ14525 1q42.13-q43 hypothetical protein FLJ14525 TTC13 1q42.2 tetratricopeptide repeat domain 13 ARV1 1q42.2 likely ortholog of yeast ARV1 MGC15887 1q42.2 hypothetical gene supported by BC009447 FLJ30430 1q42.2 hypothetical protein FLJ30430 DKFZp547B1713 1q42.2 hypothetical protein DKFZp547B1713 GNPAT 1q42.11-q42.3 glyceronephosphate O-acyltransferase EXOC8 1q42.2 exocyst complex component 8 DKFZP547N043 1q42.12-q43 hypothetical protein DKFZp547N043 EGLN1 1q42.1 egl nine homolog 1 (C. elegans) TSNAX 1q42.1 translin-associated factor X DISC1 1q42.1 disrupted in schizophrenia 1 SIPA1L2 1q42.2 signal-induced proliferation-associated 1 like 2 KIAA1383 1q42.2 KIAA1383 protein MGC13186 1q42.2 hypothetical protein MGC13186 FLJ11383 1q42.2 hypothetical protein FLJ11383 LOC148995 1q42.2 similar to 40S ribosomal protein S7 (S8) KIAA1804 1q42 mixed lineage kinase 4 KCNK1 1q42-q43 potassium channel, subfamily K, member 1 SLC35F3 1q42.3 solute carrier family 35, member F3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 5099 81.7 725 - Moskalenko (2003)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrinepancreas    
Lymphoid/Immunelymph node    
Nervousbrain    
Skin/Tegumentskin    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PH domain
  • HOMOLOGY
    interspecies homolog to murine Exoc8 (94.3 pc)
    homolog to rattus Exoc8 (93.2 pc)
    Homologene
    FAMILY
  • EXO84 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • direct target of activated Ral implicated in the regulation of a variety of dynamic cellular processes
  • involved in the docking of exocystic vesicles with fusion sites on the plasma membrane
  • with RALB, are required for nutrient starvation-induced autophagocytosis, and RALB activation is sufficient to promote autophagosome formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exocyst complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the GTP-bound forms of RALA and RALB via its PH domain
  • through direct binding to EXOC8, RALB induces the assembly of catalytically active ULK1 and Beclin1-VPS34 complexes on the exocyst, which are required for isolation membrane formation and maturation
  • deubiquitylated RALB promotes the assembly of the RALB-EXOC8-BECN1 complexes driving autophagosome formation
  • active RALA promotes the direct binding between the exocyst subunit EXOC8 and the PDZ domain of PARD6A through a non-canonical PDZ-binding motif
  • cell & other
  • binding lipids with phosphatidylinositol-3,4,5-trisphosphate groups
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS