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FLASH GENE
Symbol EXOC8 contributors: mct - updated : 22-09-2015
HGNC name exocyst complex component 8
HGNC id 24659
Location 1q42.2      Physical location : 231.468.482 - 231.473.578
Synonym name exocyst complex 84-kDa subunit
Synonym symbol(s) EXO84, SEC84, Exo84p
DNA
TYPE functioning gene
STRUCTURE 5.10 kb     1 Exon(s)
MAPPING cloned Y linked N status confirmed
Map cen - D1S2833 - D1S225 - EXOC8 - D1S251 - D1S2709 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 5099 81.7 725 - Moskalenko (2003)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrinepancreas    
Lymphoid/Immunelymph node    
Nervousbrain    
Skin/Tegumentskin    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PH domain
  • HOMOLOGY
    interspecies homolog to murine Exoc8 (94.3 pc)
    homolog to rattus Exoc8 (93.2 pc)
    Homologene
    FAMILY
  • EXO84 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • direct target of activated Ral implicated in the regulation of a variety of dynamic cellular processes
  • involved in the docking of exocystic vesicles with fusion sites on the plasma membrane
  • with RALB, are required for nutrient starvation-induced autophagocytosis, and RALB activation is sufficient to promote autophagosome formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exocyst complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the GTP-bound forms of RALA and RALB via its PH domain
  • through direct binding to EXOC8, RALB induces the assembly of catalytically active ULK1 and Beclin1-VPS34 complexes on the exocyst, which are required for isolation membrane formation and maturation
  • RALA binding to EXOC2 “activates” the Exocyst, and subsequent binding of RALA to EXOC8 “inactivates” the Exocyst for such functions
  • deubiquitylated RALB promotes the assembly of the RALB-EXOC8-BECN1 complexes driving autophagosome formation
  • active RALA promotes the direct binding between the exocyst subunit EXOC8 and the PDZ domain of PARD6A through a non-canonical PDZ-binding motif
  • cell & other
  • binding lipids with phosphatidylinositol-3,4,5-trisphosphate groups
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS