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FLASH GENE
Symbol EXOC6 contributors: mct - updated : 29-06-2016
HGNC name exocyst complex component 6
HGNC id 23196
Location 10q23.33      Physical location : 94.594.469 - 94.819.250
Synonym name
  • SEC15-like 1 (S. cerevisiae)
  • exocyst complex component Sec15A
  • Synonym symbol(s) SEC15L, FLJ1125, DKFZp761I2124, MGC33397, Sec15p, FLJ11251, SEC15L1, SEC15, EXOC6A, SEC15L3
    DNA
    TYPE functioning gene
    STRUCTURE 232.66 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 3696 - 799 - 2004 15292201
    23 - 3762 - 820 - 2004 15292201
    22 - 3650 - 804 - 2004 15292201
    22 - 3647 - 803 - 2004 15292201
    18 - 3341 - 701 - 2004 15292201
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Sec15
    Homologene
    FAMILY SEC15 family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text EXOC6 co-localizes with RAB8A in primary cilia
    basic FUNCTION
  • may be implicated in vesicle docking during exocytosis
  • its overexpression affects vesicular trafficking from the recycling endosomes and blocks the formation of primary cilia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component similar to a component of the multiprotein complex required for exocytosis in yeast
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • exocyst component EXOC6 directly interacts with RAB8A in its activated conformation
  • binding of EXOC6 to both RAB11A and RAB8A serves to coordinate vesicle budding from the recycling endosomes and vesicle tethering at the plasma membrane
  • STK38L-mediated RAB8A phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of RAB8A from phosphatidylserine (PS) to EXOC6, thereby promoting local activation of RAB8A and ciliary membrane formation
  • association of RAB10-GTP with EXOC6/6B is a molecular link between insulin signaling and the exocytic machinery in SLC2A4 translocation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    affects endosomal trafficking and blocks ciliogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS