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FLASH GENE
Symbol EXOC5 contributors: mct - updated : 19-06-2013
HGNC name exocyst complex component 5
HGNC id 10696
Location 14q22.3      Physical location : 57.669.195 - 57.735.617
Synonym name
  • SEC10-like 1 (S. cerevisiae)
  • exocyst complex component Sec10
  • Synonym symbol(s) SEC10, SEC10P, SEC10L1, DKFZp666H126, PRO1912, HSEC10
    DNA
    TYPE functioning gene
    STRUCTURE 66.42 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 8522 - 708 - 1997 9119050
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • CDC42 colocalizes with EXOC5 at the primary cilium
  • basic FUNCTION
  • regulates primary ciliogenesis
  • required for the ciliary localization of polycystin-2, thus allowing for polycystin-2 function in cellular processes
  • CDC42 and EXOC5 function in the same pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDC42 biochemically interacts with EXOC5, a crucial component of the exocyst complex
  • interacts with PKD2 (the protein product of the polycystic kidney disease 2 gene), and, when disrupted, results in MAPK pathway activation
  • directly interacts with PARD6A, a member of the PAR complex that itself directly interacts with CDC42
  • CDC42 and EXOC5 cooperate in ciliogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS