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FLASH GENE
Symbol EXOC4 contributors: mct - updated : 02-02-2011
HGNC name exocyst complex component 4
HGNC id 30389
Location 7q33      Physical location : 132.937.822 - 133.750.511
Synonym name
  • SEC8-like 1 (S. cerevisiae)
  • exocyst complex component Sec8
  • Synonym symbol(s) REC8, SEC8, Sec8p, KIAA1699, MGC27170, SEC8L1
    DNA
    TYPE functioning gene
    STRUCTURE 812.70 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1620 - 473 - 2003 12675619
    18 - 4203 - 974 - 2003 12675619
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     mouthtongue  highly
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systembreastmammary gland moderately
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-terminal consensus sequence for PDZ binding
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to rattus Sec8
    ortholog to murine Sec8l1
    homolog to C.elegans sec-8
    Homologene
    FAMILY
  • SEC8 family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text largely confined to the plasma membrane
    basic FUNCTION
  • involved in the docking of exocystic vesicles with
  • fusions site on the plasma membrane (exocyst complex)
  • EXOC3/EXOC4 complex, or exocyst, a multisubunit complex facilitating post-Golgi targeting of distinct subclasses of secretory vesicles, has been identified as a bona fide RALA effector complex
  • EXOC3/EXOC4 and septin complexes likely play an important role in trafficking vesicles and organizing proteins at the plasma membrane of neurons
  • exocyst complex EXOC3/EXOC4, serves to selectively regulate the docking of insulin-containing vesicles at sites of release close to the plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text protein transport; vesicle docking during exocytosis
    PATHWAY
    metabolism
    signaling
    a component
  • complexed with EXOC1, EXOC2, EXOC4, EXOC3, EXOC5, EXOC6, EXOC7 and EXOC8 to form exocyst complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDZ1-2 of DLG4
  • interacting with EXOC7 (assembles a multiprotein complex that includes EXOC3 and EXOC4)
  • EXOC1 and EXOC4 interact with the polarity protein IQGAP1 and this interaction is triggered by active CDC42 and RhoA, which are essential for matrix degradation
  • interaction of DLG1 with the EXOC4 exocyst component promoting membrane addition, whereas with MTMR2, negatively regulates membrane formation
  • physically interacts with EXOC4
  • cell & other
    REGULATION
    Other
  • insulin stimulates the phosphorylation of the exocyst protein EXOC4 in adipocytes
  • ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS