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FLASH GENE
Symbol EXOC3 contributors: mct - updated : 20-11-2019
HGNC name exocyst complex component 3
HGNC id 30378
Location 5p15.33      Physical location : 443.333 - 467.407
Synonym name
  • SEC6-like 1 (S. cerevisiae)
  • exocyst complex component Sec6
  • Sec 6 homolog
  • Synonym symbol(s) SEC6, Sec6p, SEC6L1
    DNA
    TYPE functioning gene
    STRUCTURE 24.07 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2774 - 745 - 1998 9655500
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly
     stomach   moderately
    Lymphoid/Immunethymus   moderately
    Reproductivefemale systemuterus  highly
     female systembreastmammary gland moderately
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Sec6l1
    ortholog to rattus Sec6
    homolog to drosophila sec6
    Homologene
    FAMILY
  • SEC6 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nuclear envelope
    text concentrated on insulin-positive vesicles
    basic FUNCTION
  • involved in the docking of exocystic vesicles with fusions site on the plasma membrane
  • EXOC3/EXOC4 and septin complexes likely play an important role in trafficking vesicles and organizing proteins at the plasma membrane of neurons
  • EXOC3/EXOC4 complex, or exocyst, a multisubunit complex facilitating post-Golgi targeting of distinct subclasses of secretory vesicles, has been identified as a bona fide RALA effector complex
  • exocyst complex EXOC3/EXOC4, serves to selectively regulate the docking of insulin-containing vesicles at sites of release close to the plasma membrane )
  • has specific functions in migration, adhesion, and cell differentiation
  • plays specific roles in cell-cell adhesion and cell cycle arrest
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exocyst complex composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EXOC7 (assembles a multiprotein complex that includes EXOC3 and EXOC4)
  • EXOC3 regulates cytoplasmic translocation of CDKN1B through CDKN1B phosphorylation at Thr157, thereby promoting CDKN1B degradation in the cytoplasm via interaction with COPS5 and SIAH1 and suppressing cell cycle progression
  • EXOC3 regulates NFKB1 transcriptional activity via the control of the phosphorylation of NFKBIA, RPS6KA2, and ERK
  • EXOC3 regulated BCL2 at the mRNA level and the binding affinity of F-box and WD repeat domain containing 7 and MCL1, thereby controlling MCL1 at the protein level
  • EXOC3 is involved in the enhancement of cell migration and suppression of apoptosis through the activation of HSPB1, HSPB2 or MAPK14 phosphorylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in early stages of non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    tumor  
    EXOC3 and EXOC4 are therapeutic target molecules in malignant peripheral nerve sheath tumors (MPNSTs)
    ANIMAL & CELL MODELS