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FLASH GENE
Symbol EXOC1 contributors: mct - updated : 02-02-2011
HGNC name exocyst complex component 1
HGNC id 30380
Location 4q12      Physical location : 56.719.815 - 56.771.244
Synonym name
  • exocyst complex component 1
  • exocyst complex component Sec3
  • SEC3-like 1 (S. cerevisiae)
  • Synonym symbol(s) SEC3, SEC3L1, Sec3p, BM-102, FLJ10893, BM-102, EX070
    DNA
    TYPE functioning gene
    STRUCTURE 51.43 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 splicing 3582 101 894 - 2001 11493706
    18 exons, the longest transcript
    18 splicing 3306 - 879 - 2001 11493706
  • lacking an in-frame exon in the coding region, resulting in a shorter isoform lacking an internal segment
  • 19 - 3426 - 894 - 2001 11493706
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivefemale systemplacenta   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two coiled-coil domains
  • HOMOLOGY
    interspecies homolog to rattus LOC305287
    Homologene
    FAMILY
  • SEC3 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • translocates to the plasma membrane in response to insulin through the activation of RHOQ, where it assembles a multiprotein complex that includes EXOC3, EXOC4 )
  • basic FUNCTION
  • involved in targeting exocytic vesicles to specific docking sites on the plasma membrane
  • in addition to functioning in exocytosis, also regulates actin at the leading edges of migrating cells, therefore coordinating cytoskeleton and membrane traffic during cell migration
  • transcriptional and translational repressor of flavivirus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exocyst complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP binding
  • protein
  • interacting with RALA in a GTP-dependent manner
  • EXOC1 and EXOC4 interact with the polarity protein IQGAP1 and this interaction is triggered by active CDC42 and RhoA, which are essential for matrix degradation
  • associates with a subset of Exocyst complexes that are enriched at desmosomes
  • ARHGEF2 and EXOC1 interact in trans-Golgi network and centrosomes, as well as in exocyst structures or complexes that move along microtubules to the plasma membrane, consistent with a functional association in both early and late stages of vesicular trafficking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS