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FLASH GENE
Symbol EVL contributors: mct/pgu - updated : 31-07-2009
HGNC name Enah/Vasp-like
HGNC id 20234
Location 14q32.32      Physical location : 100.531.750 - 100.610.572
Synonym name Ena/vasodilator-stimulated phosphoprotein-like
Synonym symbol(s) RNB6, ENA/VASP
DNA
TYPE functioning gene
STRUCTURE 78.82 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ25773 14q32.31 hypothetical protein FLJ25773 RPL3P4 14 ribosomal protein L3 pseudogene 4 BCL11B 14q32.31 B-cell CLL/lymphoma 11B (zinc finger protein) FLJ23027 14q32.32 hypothetical protein FLJ23027 CCNK 14q32 cyclin K C14orf136 14q32 chromosome 14 open reading frame 136 C14orf65 14q32.31 chromosome 14 open reading frame 65 LOC390506 14 similar to RIKEN cDNA E030025D05 gene KIAA1822 14q32 KIAA1822 CYP46A1 14q32.1 cytochrome P450, family 46, subfamily A, polypeptide 1 EML1 14q32 echinoderm microtubule associated protein like 1 LOC341965 14q32.32 similar to voltage-dependent anion channel 3 RPS2P3 14 ribosomal protein S2 pseudogene 3 EVL 14q32.32 Enah/Vasp-like C14orf66 14q32.32 chromosome 14 open reading frame 66 YY1 14q32.31-q32.32 YY1 transcription factor C14orf69 14q32.32 chromosome 14 open reading frame 69 C14orf68 14 chromosome 14 open reading frame 68 WARS 14q32.31 tryptophanyl-tRNA synthetase NDUFB3P4 14q NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 4 LOC388013 14 hypothetical gene supported by BX248767 MGC4645 14q32.32 hypothetical protein MGC4645 KIAA1446 14q32.32 brain-enriched guanylate kinase-associated protein LOC388014 14 LOC388014 DLK1 14q32 delta-like 1 homolog (Drosophila) MEG3 14q32 maternally expressed 3 LOC388015 14 similar to RTl1 LOC388016 14 LOC388016 LOC388017 14 LOC388017 LOC145197 14q32.32 hypothetical LOC145197 DIO3OS 14q32.33 deiodinase, iodothyronine, type III opposite strand DIO3 14q32 deiodinase, iodothyronine, type III LOC122423 14q32.33 similar to hypothetical protein ZC477.8 - Caenorhabditis elegans LOC388018 14 LOC388018 RPL26P4 14q32.34 ribosomal protein L26 pseudogene 3 C14orf72 14q32.33 chromosome 14 open reading frame 72 PPP2R5C 14q32.2 protein phosphatase 2, regulatory subunit B (B56), gamma isoform NPM1P20 14q32.33 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 20
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1853 45 418 - 2006 16336193
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascular     
Lymphoid/Immunelymph node    
 thymus    
Nervousbrain    
Reproductivefemale systembreastmammary gland  
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Evl (93.9pc)
homolog to rattus Evl (93.9pc)
Homologene
FAMILY
  • Ena/VASP family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text lamellipodium
    basic FUNCTION
  • involved in actin polymerization and/or depolymerization, axon guidance, cell surface receptor linked signal transduction, neurogenesis, platelet activation
  • actin-binding protein, recruited at focal adhesions
  • promotes single-stranded DNA annealing
  • novel recombination factor that may be required for repairing specific DNA lesions
  • potential oncogene
  • implicated in a variety of fundamental cellular processes including axon guidance and cell migration
  • EVL-mediated filament elongation displays a saturation dependence on the actin monomer concentration, implying that EVL proteins, independent of species, are fully saturated with actin and generally act as potent filament elongators
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between SPTAN1, TES and EVL indicate new functions for spectrin in actin dynamics and focal adhesions
  • binds to RAD51 and RAD51L1 and stimulates the RAD51-mediated homologous pairing and strand exchange
  • interacting with spectrin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    up-regulated in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS