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FLASH GENE
Symbol EVI2B contributors: SGE/npt - updated : 09-03-2010
HGNC name ecotropic viral integration site 2B
HGNC id 3500
Location 17q11.2      Physical location : 29.630.787 - 29.641.130
Synonym name
  • murine myeloid leukemia associated gene (Evi-2) homolog B
  • ecotropic viral integration site 2B protein homolog
    • Synonym symbol(s) EVDB, D17S376, EVI-2B
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text embedded in NF1 first intron in opposite orientation
    STRUCTURE 10.34 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2009 - 448 - Cawthon 1991
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal peptide
  • an extracellular domain
  • four potential glycosylation sites
  • a single hydrophobic transmembrane domain
  • a cytoplasmic hydrophilic domain
    • conjugated GlycoP , PhosphoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Evi2b
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in melanocyte and keratinocyte differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS