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FLASH GENE
Symbol ETV5 contributors: mct - updated : 04-03-2019
HGNC name ets variant 5
HGNC id 3494
Location 3q27.2      Physical location : 185.764.107 - 185.826.901
Synonym name
  • Ets-related molecule
  • ets variant gene 5 (ets-related molecule)
  • ets-related protein ERM
    • Synonym symbol(s) ERM
    DNA
    TYPE functioning gene
    STRUCTURE 62.80 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 4102 57.8 510 - - 8661127
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
     male systemtestis    Homo sapiens
     male systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveSertoli cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, other tissues involved in development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal transactivation domain (TAD) whose activity is inhibited by small ubiquitin-like modifier (SUMO), and by a flanking domain named the negative regulatory domain (NRD)
  • ETS DNA binding domain, PEA3 subgroup
  • two transcriptional activation domains
  • N- and C-terminal transactivating domains also containing an alpha-helix
    • HOMOLOGY
    interspecies ortholog to murine Etv5
    Homologene
    FAMILY
  • PEA3 group of the Ets transcription factor family
  • divergent member of the winged helix-turn-helix superfamily
  • ETS family
    • CATEGORY adaptor , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating transcription
  • having a role in progression of breast cancer
  • role of adaptor molecule in the interactions of adhesion receptors and intracellular tyrosine kinases
  • is required for spermatogonial stem cell self-renewal
  • pivotal and complementary roles of ETV4 and ETV5 transcription factors in events crucial to mammary tumorigenesis
  • regulate growth cone and coordinate membrane and actin dynamics in responses to SEMA3A
  • with ETV4, are key components of a gene network downstream of Ret that promotes and controls renal branching morphogenesis
  • important factor for the self-renewal of Spermatogonial stem cells (SSCs) and the maintenance of spermatogenesis
  • directly regulates CXCL12 gene expression by interacting with its cis-acting element in response to FGF2 stimulation in Sertoli cells
  • plays important roles in development and tumorigenesis
  • having a direct role on epithelial-to-mesenchymal transition (EMT)
  • ETV4 and ETV5 are essential molecules of the transcriptional program linking neurotrophin signaling to sensory neuronal differentiation, suggesting that they can be involved in NGF-mediated target innervation
  • is a transcription factor that is required for fertility
  • physiological role for ETV5 in many aspects of development including embryonic and perinatal survival, postnatal growth, limb patterning, kidney development and fertility
  • is a signal transducer and activator of transcription 3-induced positive regulator of TH17 development
  • ETV4 and ETV5, potentially through regulation of GBX2 and TCF15, are involved in the ES cell proliferation and induction of differentiation-associated genes in ES cells
  • ETV5 and SPI1 function in parallel to promote Th9 cell development
  • ETV5 is a transcription factor responsible for maintaining the spermatogonial stem cell niche
  • ETV5 plays a crucial role in regulating IL10 production in Th2 cells by facilitating the binding of IL10-inducing transcription factors at the IL10 locus
  • ETV5 is a critical output of RAS signaling in alveolar type II (AT2) cells, contributing to both lung homeostasis and tumor initiation
  • regulates ductal morphogenesis with SOX9 and is critical for regeneration from pancreatitis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to sequences containing the consensus pentanucleotide 5'-CGGA(AT)-3'
    RNA
    small molecule
    protein
  • RFWD2 is a tumour suppressor that negatively regulates ETV1, ETV4 and ETV5
  • ETV5 modulated ZEB1 expression and CDH1 repression leading to a complete reorganization of cell-cell and cell-substrate contacts
  • FGF2 depends on MAP2K1 signaling to drive spermatogonial stem cell (SSC) self-renewal via upregulation of the ETV5 and BCL6B genes
  • SOX9 regulation of ETV5 contributes to the control of male fertility
  • ETV5 could transactivate GHRL promoter region and increase its expression, leading to subsequent increase in the production of acyl ghrelin
    • cell & other
    REGULATION
    inhibited by SUMO modification
    Other gene expression is regulated by the PKC pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice with targeted disruption of ETV5 have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and Sertoli-cell-only syndrome