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FLASH GENE
Symbol ETV3 contributors: - updated : 27-12-2005
HGNC name ets variant gene 3
HGNC id 3492
Location 1q21-q23      Physical location : 157.094.458 - 157.108.383
Synonym symbol(s) PE1, METS, PE-1
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RHBG 1q21.3 Rhesus blood group, B glycoprotein CROC4 1q12-q25 Rhesus blood group, B glycoprotein MEF2D 1q12-q23 MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) IQGAP3 1q21.3 IQ motif containing GTPase activating protein 3 LOC164118 1q23.1 similar to RIKEN cDNA A430025D11 APOA1BP 1q21.2 apolipoprotein A-I binding protein FLJ20249 1q22 hypothetical protein FLJ20249 BRAL1 1q22 hypothetical protein FLJ20249 BCAN 1q23-q31 hypothetical protein FLJ20249 NES 1q23.1 nestin CRABP2 1q21.3 cellular retinoic acid binding protein 2 FLJ12671 1q23.1 hypothetical protein FLJ12671 CGI-41 1q23.1 CGI-41 protein MRPL24 1q21-q22 mitochondrial ribosomal protein L24 HDGF Xq25 hepatoma-derived growth factor (high-mobility group protein 1-like) PRCC 1q21.2 papillary renal cell carcinoma (translocation-associated) SH2D2A 1q21 SH2 domain protein 2A INSRR 1q21-q23 insulin receptor-related receptor NTRK1 1q22 neurotrophic tyrosine kinase, receptor, type 1 FLJ00193 1q23.1 FLJ00193 protein FLJ32884 1q23.1 hypothetical protein FLJ32884 ARHGEF11 1q21-q23 Rho guanine nucleotide exchange factor (GEF) 11 LOC246784 1q21.3 homolog of C. elegans smu-1 pseudogene LOC149501 1q23.1 similar to KRT8 protein HCP2 1q22 cytochrome c, somatic pseudogene ETV3 1q21-q23 ets variant gene 3 IRTA2 1q21 ets variant gene 3 IRTA1 1q21 ets variant gene 3 LOC391105 1 similar to dJ801G22.2 (novel protein similar to immunoglobulin gamma FC receptor 1 (FGCR1)) FCRH3 1q21-q22 Fc receptor-like protein 3 LOC148300 1q23.1 son-pseudogene LOC391106 1 similar to voltage-dependent anion channel 1 SPAP1 1q21 SH2 domain containing phosphatase anchor protein 1 FCRH1 1q21-q22 Fc receptor-like protein 1 CD5L 1q21-q23 CD5 antigen-like (scavenger receptor cysteine rich family) MRPS21P2 1q22 mitochondrial ribosomal protein S21 pseudogene 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines numerous cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
ETS DNA-binding domain, PEA3 group
HOMOLOGY
Homologene
FAMILY
  • transcription factor of the ETS family, PEA3 subgroup
  • divergent member of the winged helix-turn-helix superfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional repressor contributing to growth arrest during terminal macrophage differentiation by repressing target genes involved in RAS-dependent proliferation
  • acting as regulator of macrophage differentiation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to sequences containing the consensus pentanucleotide 5'-CGGA(AT)-3'
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS