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FLASH GENE
Symbol ETFB contributors: npt/ - updated : 24-07-2006
HGNC name electron-transfer-flavoprotein, beta polypeptide
HGNC id 3482
Corresponding disease
ETFB glutaric aciduria IIB, early onset
Location 19q13.33      Physical location : 51.848.409 - 51.869.672
Synonym name
  • electron transfer flavoprotein beta subunit
  • beta-ETF
    • Synonym symbol(s) MADD, FP585
    DNA
    TYPE functioning gene
    STRUCTURE 9.70 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    KLK6 19q13.3 kallikrein 6 (neurosin, zyme) KLK7 19q13.41 kallikrein 7 (chymotryptic, stratum corneum) KLK8 19q13.3 kallikrein 8 (neuropsin/ovasin) KLK9 19q13.3-q13.4 kallikrein 9 KLK10 19q13.3 kallikrein 10 KLK11 19q13.3-q13.4 kallikrein 11 KLK12 19q13.3-q13.4 kallikrein 12 KLK13 19q13.2-q13.4 kallikrein 13 KLK14 19q13.3-q13.4 kallikrein 14 LOC90353 19q13.41 LOC90353 SIGLEC9 19q13.4 sialic acid binding Ig-like lectin 9 SIGLEC7 19q13.3 sialic acid binding Ig-like lectin 7 LOC284367 19q13.41 hypothetical protein LOC284367 SIGLECP1 19q13.33 sialic acid binding Ig-like lectin, pseudogene 1 CD33 19q13.3 CD33 antigen (gp67) FLJ40235 19q13.41 hypothetical protein FLJ40235 LOC339351 19q13.41 similar to hypothetical protein LOC162952 19q13.41 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) LOC147645 19q13.41 hypothetical protein LOC147645 ETFB 19q13.4 electron-transfer-flavoprotein, beta polypeptide MGC33839 19q13.41 hypothetical protein MGC33839 NKG7 19q13.4 natural killer cell group 7 sequence LIM2 19q13.4 lens intrinsic membrane protein 2, 19kDa LOC147646 19q13.41 hypothetical protein LOC147646 LOC388557 19 similar to nucleolar phosphoprotein Nopp34 SIGLEC10 19q13.3 sialic acid binding Ig-like lectin 10 SIGLEC8 19q13.33-q13.41 sialic acid binding Ig-like lectin 8 SIGLECL1 19q13.4 SIGLEC-like 1 SIGLEC6 19q13.3 sialic acid binding Ig-like lectin 6 ZNF175 19q13.4 zinc finger protein 175 LOC147649 19q13.41 hypothetical LOC147649 LOC339352 19q13.41 hypothetical LOC339352 SIGLEC5 19q13.4 sialic acid binding Ig-like lectin 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 933 - 255 - Toogood
    - - 1318 - 316 - Toogood
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • ETF beta-subunit/FIXA family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of an alpha and a beta subunit
    • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • binds a FAD per dimer,
  • binds a AMP per subunit
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ETFB
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS