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FLASH GENE
Symbol ESX1 contributors: mct - updated : 28-06-2012
HGNC name extraembryonic, spermatogenesis, homeobox 1 homolog (mouse)
HGNC id 14865
Location Xq22.2      Physical location : 103.494.719 - 103.499.599
Synonym name extraembryonic, spermatogenesis, homeobox 1-like
Synonym symbol(s) ESXR1, ESX1L
DNA
TYPE functioning gene
STRUCTURE 4.88 kb     4 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1591 - 406 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainmedulla oblongata  
Reproductivefemale systemplacenta   
 male systemmale genital tractseminiferous tubule  
 male systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatogonia
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text embryonic development, in distinct epidermal patterns in head, thorax and abdomen and in an endodermal pattern in the anterior intestinal tract,placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal 45-kDa fragment containing the paired-like homeodomain, localized to the nucleus, acting as a sequence-specific transcriptional repressor
  • C-terminal 20-kDa fragment localizes to the cytoplasm and inhibits the degradation of mitotic cyclins, thereby inducing M phase cell-cycle arrest
  • one OAR domain
  • glutamic acid-rich and proline-rich N- and C-terminal regions
  • 12 repeats of a unique nine amino acid motif, PPMAP(V/L)PPG, located C-terminal to the homeodomain
  • HOMOLOGY
    interspecies ortholog to murine ESX1
    Homologene
    FAMILY paired homeobox family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • homeoprotein involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages
  • plays a role in concerted regulation of the cell cycle and transcription in cells
  • may be playing a role in post-meiotic germ cell development
  • involved in placental development and spermatogenesis
  • playing a potential role within the growth control mechanism of the fetus, through its effect on placental function
  • required for the translocation of Mycobacterium tuberculosis or Mycobacterium marinum to the cytosol of host cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with the TAATGTTATTA sequence that is present within the first intron of the K-ras gene termed REK, and represses KRAS transcription
  • NRK and ESX1 may participate in the same signaling pathway that regulates placental development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in human pre-term idiopathic fetal growth restriction
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potentially reliable spermatogenesis molecular marker
  • Therapy target potential clinical application of TAT-mediated transduction of N-ESX1 in the treatment of cancers with K-ras mutations
    ANIMAL & CELL MODELS