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FLASH GENE
Symbol ESRRG contributors: mct - updated : 03-06-2020
HGNC name estrogen-related receptor gamma
HGNC id 3474
Location 1q41      Physical location : 216.676.587 - 217.311.097
Synonym name
  • ERR gamma-2
  • nuclear receptor subfamily 3 group B member 3
  • Synonym symbol(s) ERRB, KIAA0832, ERRG2, ERR3, NR3B3, FLJ16023, KIAA0832, DKFZp781L1617
    DNA
    TYPE functioning gene
    STRUCTURE 634.46 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 5195 51 458 - 2019 30954508
    9 - 5380 - 435 - 2019 30954508
    8 - 5213 - 435 - 2019 30954508
    9 - 5261 - 435 - 2019 30954508
    10 - 5434 - 435 - 2019 30954508
    9 - 5255 - 435 - 2019 30954508
    8 - 5137 - 435 - 2019 30954508
    7 - 4724 - 207 - 2019 30954508
    10 - 5576 - 435 - 2019 30954508
    9 - 5332 - 435 - 2019 30954508
    7 - 4797 - 273 - 2019 30954508
    9 - 5411 - 435 - 2019 30954508
    7 - 5714 - 435 - 2019 30954508
    8 - 5299 - 435 - 2019 30954508
    7 - 5452 - 435 - 2019 30954508
    8 - 5623 - 396 - 2019 30954508
    9 - 5279 - 435 - 2019 30954508
    9 - 5490 - 435 - 2019 30954508
    8 - 5344 - 470 - 2019 30954508
    9 - 5559 - 435 - 2019 30954508
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland    
    Hearing/Equilibriumear   highly
    Nervousbrain   highly
     spinal cord    
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tracttrachea   
    Urinarykidney   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposebrown   Homo sapiens
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal highly
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • receptor composed of a N terminal modulator domain
  • a central bipartite zinc finger DNA binding domain
  • a nuclear localization signal (NLS)
  • a C terminal ligand binding domain
  • a transactivation and dimerization domain
  • HOMOLOGY
    Homologene
    FAMILY
  • orphan receptor family
  • steroid/thyroid hormone receptor superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • orphan nuclear receptor, acting as transcription activator in the absence of bound ligand
  • binds specifically to an estrogen response element and
  • activates reporter genes controlled by estrogen response elements
  • is required for early branching events of the ureteric duct that occur prior to the onset of nephrogenesis
  • is a novel downstream mediator of glucagon action in hepatic gluconeogenesis
  • potential role of ESRRG in maternal blood pressure homeostasis during pregnancy, suggesting that aberrant ESRRG expression may contribute to the pathogenesis of preeclampsia
  • ESRRG plays a role in maintenance of hearing
  • neuronal ESRRG is invoved in the metabolic adaptations required for memory formation
  • regulates testicular steroidogenesis, both directly controlling and indirectly fine-tuning the expression of steroidogenic genes
  • is a novel catabolic regulator of osteoarthritis (OA) pathogenesis
  • role for ESRRG as a critical thermoneutral maintenance factor required to prime Brown adipose tissue (BAT) for thermogenesis
  • ESRRG is a pivotal regulator in TNFSF11-mediated osteoclastogenesis
  • ESRRA and ESRRG are critical regulators of cardiac myocyte maturation, serving as transcriptional activators of adult cardiac metabolic and structural genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    estrogen
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLK2 is a novel target of ESRRG, and this interaction is crucial for cancer cell proliferation
  • overexpression of ESRRG induced PCK1 and G6PC gene expression and glucose production in primary hepatocytes
  • ESRRG directly regulated the CYP17A1 promoter
  • ESRRG is a novel transcriptional regulator of human fibrinogen gene expression
  • functions as a negative regulator in receptor activator of TNFSF11-induced osteoclast differentiation
  • ESRRG mediates alcohol-induced hepatic lipogenesis by upregulating SREBF1 expression, which can be blunted by the inverse agonist for ESRRG
  • cell & other
    REGULATION
    activated by not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in postmenopausal vaginal mucosa
    constitutional       gain of function
    in cartilage from human osteoarthritis (OA) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for CAKUT
    Marker
  • ESRRG promoter methylation could be a diagnostic and prognostic biomarker in Laryngeal Squamous Cell Carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    control of hepatic glucose production by an ESRRG-specific inverse agonist is a new potential therapeutic approach for the treatment of type 2 diabetes
    digestiveliver 
    inverse agonist for ESRRG, may be an attractive therapeutic strategy for the treatment of alcoholic fatty liver disease
    osteoarticularboneostéoporosis
    potential therapeutic target for pathological bone loss
    ANIMAL & CELL MODELS
  • mouse embryos with a targeted inactivation of Esrrg on both alleles (Esrrg(-/-) showed agenesis of the renal papilla but normal development of the cortex and remaining medulla