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FLASH GENE
Symbol ESRRG contributors: mct - updated : 27-05-2008
HGNC name estrogen-related receptor gamma
HGNC id 3474
Location 1q41      Physical location : 216.676.587 - 217.311.097
Synonym name
  • ERR gamma-2
  • nuclear receptor subfamily 3 group B member 3
  • Synonym symbol(s) ERRB, KIAA0832, ERRG2, ERR3, NR3B3
    DNA
    TYPE functioning gene
    STRUCTURE 586.00 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ32796 1q32.3 hypothetical protein FLJ32796 LOC388735 1 LOC388735 SNFT 1q32.3 Jun dimerization protein p21SNFT DC8 1q41 DKFZP566O1646 protein LOC388736 1 similar to ribosomal protein S5; 40S ribosomal protein S5 LOC149643 1q32.3 hypothetical LOC149643 FLVCR 1q32.1-q32.2 hypothetical LOC149643 FLJ12505 1q32.3 hypothetical protein FLJ12505 LOC90806 1q32.3 similar to RIKEN cDNA 2610307I21 RPS6KC1 1q41 ribosomal protein S6 kinase, 52kDa, polypeptide 1 LOC391161 1 similar to ribosomal protein L31 PROX1 1q32.2-q32.3 prospero-related homeobox 1 SMYD2 1q32.3 SET and MYND domain containing 2 PTPN14 1q32.2 protein tyrosine phosphatase, non-receptor type 14 CENPF 1q32-q41 centromere protein F, 350/400ka (mitosin) LOC391162 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) KCNK2 1q41 potassium channel, subfamily K, member 2 LOC391163 1 similar to Voltage-dependent anion-selective channel protein 1 (VDAC-1) (mVDAC1) (mVDAC5) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) KCTD3 1q41 potassium channel tetramerisation domain containing 3 LOC388737 1 similar to bA275K8.2 (novel protein with weak homology to human Usher syndrome type 2A and NGCAM-related cell adhesion molecule proteins and rat glomerular mesangial cell receptor protein-tyrosine phosphatase) LOC391164 1 similar to protein tyrosine phosphatase, receptor type, Q isoform 1 precursor; glomerular mesangial cell receptor protein-tyrosine phosphatase LOC200125 1q41 similar to laminin A-chain USH2A 1q41 Usher syndrome 2A (autosomal recessive, mild) MRPS18BP1 6q22.33 mitochondrial ribosomal protein S17 pseudogene 5 ESRRG 1q32 estrogen-related receptor gamma FLJ10252 1q41 hypothetical protein FLJ10252 LOC128153 1q41 hypothetical protein BC014608 UBBP2 1q32 ubiquitin B pseudogene 2 CGI-115 1q41 CGI-115 protein LOC391165 1 similar to 40S ribosomal protein S26 TGFB2 1q41 transforming growth factor, beta 2 LYPLAL1 1q41 lysophospholipase-like 1 LOC388738 1 LOC388738 LOC388739 1 similar to KIAA0663 gene product DKFZp547M236 EPRS 1q41 glutamyl-prolyl-tRNA synthetase BPNT1 1q41 3'(2'), 5'-bisphosphate nucleotidase 1 FLJ10326 1q42.11 mitochondrial isoleucine tRNA synthetase RAB3-GAP150 1q42.12 mitochondrial isoleucine tRNA synthetase MORF4LP1 1q4.1-4.2 mortality factor 4 like pseudogene 1 LOC127086 1q42.11 similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 5253 51 458 - Matsushima (2007)
    10 - 5369 - 435 - Matsushima (2007)
    8 - 5251 - 435 - Matsushima (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland    
    Hearing/Equilibriumear   highly
    Nervousbrain   highly
     spinal cord    
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tracttrachea   
    Urinarykidney   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal highly
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • receptor composed of a N terminal modulator domain
  • a central bipartite zinc finger DNA binding domain
  • a nuclear localization signal (NLS)
  • a C terminal ligand binding domain
  • a transactivation and dimerization domain
  • HOMOLOGY
    Homologene
    FAMILY
  • orphan receptor family
  • steroid/thyroid hormone receptor superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • orphan nuclear receptor, acting as transcription activator in the absence of bound ligand
  • binds specifically to an estrogen response element and
  • activates reporter genes controlled by estrogen response elements
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    estrogen
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein PLK2 is a novel target of ESRRG, and this interaction is crucial for cancer cell proliferation
    cell & other
    REGULATION
    activated by not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in postmenopausal vaginal mucosa
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS