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FLASH GENE
Symbol ESRRA contributors: mct/npt - updated : 03-01-2009
HGNC name estrogen-related receptor alpha
HGNC id 3471
Location 11q13.1      Physical location : 64.073.043 - 64.084.210
Synonym name
  • estrogen receptor-like 1
  • nuclear receptor subfamily 3 group B member 1
  • Synonym symbol(s) ERR1, ERRa, ESRL1, NR3B1, ERRALPHA
    DNA
    TYPE functioning gene
    STRUCTURE 11.20 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC283248 11q13.1 hypothetical protein LOC283248 FLJ13848 11q13.1 hypothetical protein FLJ13848 COX8 11q13.1 cytochrome c oxidase subunit VIII OTUB1 11q13.1 OTU domain, ubiquitin aldehyde binding 1 LRP16 11q11 LRP16 protein LOC387776 11 LOC387776 FLRT1 11q12-q13 fibronectin leucine rich transmembrane protein 1 STIP1 11q13.2 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) URP2 11q13.1 UNC-112 related protein 2 short form MGC11134 11q13.1 tRNA splicing 2' phosphotransferase 1 MGC13045 11q13.1 hypothetical protein MGC13045 DNAJC4 11q13 DnaJ (Hsp40) homolog, subfamily C, member 4 VEGFB 11q13 vascular endothelial growth factor B FKBP2 11q13.1 FK506 binding protein 2, 13kDa PPP1R14B 11q13 protein phosphatase 1, regulatory (inhibitor) subunit 14B PLCB3 11q13.1-q13.2 phospholipase C, beta 3 (phosphatidylinositol-specific) BAD 11q12.3 BCL2-antagonist of cell death C11ORF4 11cen-q22.3 chromosome 11 hypothetical protein ORF4 KCNK4 11q13 potassium channel, subfamily K, member 4 ESRRA 11q12-q13 estrogen-related receptor alpha HSPC152 11q13.1 hypothetical protein HSPC152 PRDX5 11q13.1 peroxiredoxin 5 FLJ37970 11q12.3 hypothetical protein FLJ37970 RPS6KA4 11q11-q13 ribosomal protein S6 kinase, 90kDa, polypeptide 4 LOC387777 11 LOC387777 FLJ37045 11q13.1 hypothetical protein FLJ37045 SLC22A11 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 11 SLC22A12 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 12 NRXN2 11q13.2 neurexin 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2221 45.4 423 - Stein (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemuterus   
     female systemuteruscervix highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal modulator domain
  • a central bipartite zinc finger DNA binding domain
  • a nuclear localization signal (NLS)
  • a C terminal ligand binding domain
  • a transactivation and dimerization domain
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • orphan receptors family
  • nuclear hormone receptor family
  • NR3 subfamily
  • CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • estrogen-related receptor A
  • regulator of medium chain acyl CoA dehydrogenase
  • involved in the expression of SV40 major late promoter
  • modulator of ESR response of lactoferrin promoter
  • repressor of the peroxisome proliferator-associated receptor gamma coactivator 1
  • required for the basal level of expression of many known and novel ESRRA target genes
  • playing a role in breast cancer growth
  • activates the expression of androgen response elements (ARE)-containing promoters, such as that of the prostate cancer marker PSA, in an ARE-dependent manner
  • important mediator of mitochondrial biogenesis and function, and a key regulator of oxidative metabolism
  • potential interactant for co-activators and co-repressors of transcription, only a few co-activators have been shown to support ESRRA function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    estrogen
    a component ESRRA, PPARGC1A, and BCL3 form a complex on an ESRRA-responsive element within the pyruvate dehydrogenase kinase 4 gene promoter in cardiac myocytes (Yang 2009)
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • ESRRA interacts with and is acetylated by EP300 coactivator associated factor (KAT2B)
  • direct interaction of NRF1 and ESRRA with PPARGC1B, and their participation in mitochondrial biogenesis and respiration
  • cell & other
    REGULATION
    Other induced and activated by PPARGC1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS