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FLASH GENE
Symbol ESRP1 contributors: mct - updated : 27-04-2015
HGNC name epithelial splicing regulatory protein 1
HGNC id 25966
Location 8q22.1      Physical location : 95.653.363 - 95.719.692
Synonym name
  • RNA-binding motif protein 35A
  • RNA-binding protein 35A
  • Synonym symbol(s) RBM35A, RMB35A
    DNA
    TYPE functioning gene
    STRUCTURE 66.33 kb     16 Exon(s)
    regulatory sequence Promoter
    text structure
  • transcription repressor SNAI1 binds to E-boxes in the ESRP1 promoter, causing repression of the ESRP1 gene
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3805 - 681 - 2009 19829082
    14 - 3545 - 608 - 2009 19829082
    16 - 3794 - 677 - 2009 19829082
    15 - 3684 - 659 - 2009 19829082
    14 - 3533 - 604 - 2009 19829082
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • ESRP1 and ESRP2 are coordinators of an epithelial cell-type-specific splicing program
  • ESRP1 and ESRP2 are cell-type-specific regulators of transcripts that switch splicing during the epithelial-mesenchymal transition (EMT)
  • could be a master regulator of the EMT process in pituitary adenomas causing acromegaly
  • could play an important role in the morphological changes underlying embryogenesis of the placenta and embryo
  • ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in corneal cells to maintain or enhance epithelial characteristics
  • may function prominently as a master regulator of the EMT process in pituitary adenomas causing acromegaly
  • ESRP1 and ESRP2 regulate alternative splicing events associated with epithelial phenotypes of cells, and both are down-regulated during the epithelial-mesenchymal transition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of ESRP1 and ESRP2 is thus closely associated with a motile phenotype of cancer cells
    tumoral     --over  
    was associated with longer survival in comparison with low ESRP1 expression in pancreatic carcinoma (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    devising mechanisms to upregulate ESRP1 may exert a beneficial therapeutic effect in PDAC
    ANIMAL & CELL MODELS